Evidence map›Paper›PMID 34438471›Full record

ArticleImmunity, inflammation and disease2021

Ferritin level: A predictor of severity and mortality in hospitalized COVID-19 patients.

Moudhi Alroomi, Rajesh Rajan, Abdulaziz A Omar, Ahmad Alsaber, Jiazhu Pan, Mina Fatemi, Kobalava D Zhanna, Wael Aboelhassan, Farah Almutairi, Naser Alotaibi and 7 more

Abstract read
In one paragraph

Article in Immunity, inflammation and disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

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  13. Iron and iron-related proteins in COVID-19.Clinical and experimental medicine · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Moudhi AlroomiDepartment of Infectious Diseases, Infectious Diseases Hospital, Shuwaikh Medical Area, Kuwait City, Kuwait.ORCID 0000-0001-6907-011X
Rajesh RajanDepartment of Cardiology, Sabah Al Ahmad Cardiac Centre, Al Amiri Hospital, Kuwait City, Sharq, Kuwait.ORCID 0000-0002-0249-0440
Abdulaziz A OmarDepartment of Medicine, Jaber Al Ahmed Hospital, South Surra, Kuwait.
Ahmad AlsaberDepartment of Mathematics and Statistics, University of Strathclyde, Glasgow, United Kingdom.ORCID 0000-0001-9478-0404
Jiazhu PanDepartment of Mathematics and Statistics, University of Strathclyde, Glasgow, United Kingdom.ORCID 0000-0001-7346-2052
Mina FatemiPublic Health and Commissioning Manager, Nottinghamshire County Council, Nottingham, United Kingdom.ORCID 0000-0002-0208-2498
Kobalava D ZhannaDepartment of Internal Medicine with the Subspecialty of Cardiology and Functional Diagnostics Named after V.S. Moiseev, Peoples' Friendship University of Russia (RUDN University), Moscow, Russian Federation.ORCID 0000-0003-1126-4282
Wael AboelhassanDivision of Gastroenterology, Department of Medicine, Jaber Al Ahmed Hospital, South Surra, Kuwait.
Farah AlmutairiDepartment of Medicine, Farwaniya Hospital, Farwaniya, Kuwait.
Naser AlotaibiDepartment of Medicine, Al Adan Hospital, Hadiya, Kuwait.
Mohammad A SalehDepartment of Medicine, Farwaniya Hospital, Farwaniya, Kuwait.
Noor AlNasrallahDepartment of Medicine, Al Adan Hospital, Hadiya, Kuwait.
Bader Al-BaderDepartment of Medicine, Farwaniya Hospital, Farwaniya, Kuwait.
Haya MalhasDepartment of Emergency Medicine, Mubarak Al-Kabeer Hospital, Jabriya, Kuwait.
Maryam RamadhanDepartment of Obstetrics and Gynaecology, Maternity Hospital, Shuwaikh Medical Area, Kuwait City, Kuwait.
Mohammed AbdullahDepartment of Infectious Diseases, Infectious Diseases Hospital, Shuwaikh Medical Area, Kuwait City, Kuwait.
Hassan AbdelnabyDepartment of Endemic and Infectious Diseases, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis study aims to investigate in-hоsрitаl mоrtаlity in severe асute resрirаtоry syndrоme соrоnаvirus 2 раtients strаtified by serum ferritin levels.

methodsPatients were stratified based on ferritin levels (ferritin levels ≤ 1000 or >1000).

resultsApproximately 89% (118) of the patients with ferritin levels > 1000 had pneumonia, and 51% (67) had hypertension. Fever (97, 73.5%) and shortness of breath (80, 61%) were two major symptoms among the patients in this group. Logistic regression analysis indicated that ferritin level (odds ratio [OR] = 0.36, 95% confidence interval [CI] = 0.21-0.62; p < .001), male sex (OR = 2.63, 95% CI = 1.43-5.06; p = .003), hypertension (OR = 4.16, 95% CI = 2.42-7.36; p < .001) and pneumonia (OR = 8.48, 95% CI = 3.02-35.45; p < .001) had significance in predicting in-hospital mortality. Additionally, the Cox proportional hazards analysis and Kaplan-Meier survival probability plot showed a higher mortality rate among patients with ferritin levels > 1000.

conclusionIn this study, higher levels of serum ferritin were found to be an independent predictor of in-hоsрitаl mоrtаlity.

Indexed as

COVID-19PneumoniaFerritinsHumansMaleSARS-CoV-2FerritinsCOVID-19ferritinhypertensionin-hospital mortalitymale sexpneumoniaSARS-CoV-2

Identifiers

PMID34438471
PMCPMC8589386

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.