Evidence map›Paper›PMID 34438316›Full record

ArticleCancer epidemiology2021

Increasing Area Deprivation Index negatively impacts ovarian cancer survival.

Demetra H Hufnagel, Dineo Khabele, Fiona E Yull, Pamela C Hull, Joellen Schildkraut, Marta A Crispens, Alicia Beeghly-Fadiel

Abstract read
In one paragraph

Article in Cancer epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. Socioeconomic disadvantage and the risk for adverse post-operative outcomes after gynecologic cancer surgery.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2025
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  14. A Comparison of Neighborhood Socioeconomic Deprivation Measures and the Association with Survival among Black and White Women with Endometrial Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Demetra H HufnagelVanderbilt University School of Medicine, Nashville, TN 37240, USA; Department of Obstetrics and Gynecology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Dineo KhabeleDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis, MO 63130, USA.
Fiona E YullDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37212, USA; Department of Obstetrics & Gynecology, Division of Gynecologic Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt-Ingram Cancer Center, Nashville, TN 37232, USA.
Pamela C HullDivision of Population Science and Community Impact, University of Kentucky, Markey Cancer Center, Lexington, KY 40536, USA.
Joellen SchildkrautDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
Marta A CrispensDepartment of Obstetrics & Gynecology, Division of Gynecologic Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt-Ingram Cancer Center, Nashville, TN 37232, USA.
Alicia Beeghly-FadielVanderbilt-Ingram Cancer Center, Nashville, TN 37232, USA; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37203, USA. Electronic address: alicia.beeghly@vumc.org.

Funding

TrainingU54CA163072 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Tuya Pal, Karen Marie Winkfield · 2011 to 2026
$20.1M
Training and Mentoring CoreU54MD010722 · NIMHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COX, NANCY J · 2016 to 2020
$11.9M
Macrophage-based ovarian cancer immunotherapyR01CA214043 · NCI · VANDERBILT UNIVERSITY · PI GIORGIO, TODD D, KHABELE, DINEO · 2017 to 2021
$1.9M
NCI NIH HHS R01 CA214043NCI NIH HHS U54 CA163072NIMHD NIH HHS U54 MD010722
6 · The paper itself

Abstract

introductionWhile individual-level measures of socioeconomic status have been well-studied in relation to ovarian cancer survival, no studies to date have examined both state and national-level Area Deprivation Indices (ADIs), which incorporate neighborhood affluence and resources.

methodsWe abstracted clinical data from medical records for ovarian cancer cases from the Vanderbilt University Medical Center and obtained ADIs from the Neighborhood Atlas®. Associations with clinical characteristics were assessed with Spearman correlations and Kruskal-Wallis tests; associations with progression-free survival (PFS) and overall survival (OS) were assessed with Cox proportional-hazards regression.

resultsAmong 184 cases, state and national ADIs were highly correlated, but not related to any cancer characteristics. In multivariable adjusted regression models, both were significantly associated with OS; each decile increase in state or national ADI corresponded to a 9 % or 10 % greater risk of death, respectively.

conclusionsIncreasing area-level deprivation may negatively impact ovarian cancer survival.

Indexed as

Ovarian NeoplasmsCarcinoma, Ovarian EpithelialFemaleHumansProgression-Free SurvivalProportional Hazards ModelsResidence CharacteristicsSocial ClassOvarian neoplasmsPrognosisSocioeconomic factorsSurvival

Identifiers

PMID34438316
PMCPMC10310307

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.