Evidence map›Paper›PMID 34437887›Full record

ReviewChest2022

Addressing Race in Pulmonary Function Testing by Aligning Intent and Evidence With Practice and Perception.

Nirav R Bhakta, David A Kaminsky, Christian Bime, Neeta Thakur, Graham L Hall, Meredith C McCormack, Sanja Stanojevic

Open access · hybridAbstract readReview
In one paragraph

Review in Chest, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 3 pooled it
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 3 syntheses or guidelines pooled it, 96 citations in OpenAlex.

  1. Race-Based Pulmonary Function Testing Correction in COPD Inhaler Therapy Trials: A Systematic Review.International journal of chronic obstructive pulmonary disease · 2024
    Pooled it
  2. Guideline
  3. Pooled it
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Implications of removing race from spirometry reference equations in children with asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2025
    Article
  12. Bronchodilator Response in COPD: Definitions, Reference Equations, and Race.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2025
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 3 countries.

Nirav R BhaktaDepartment of Medicine, University of California, San Francisco, San Francisco, CA. Electronic address: nirav.bhakta@ucsf.edu.
David A KaminskyUniversity of Vermont, Burlington, VT.
Christian BimeCollege of Medicine, The University of Arizona Health Science, Tucson, AZ.
Neeta ThakurDepartment of Medicine, University of California, San Francisco, San Francisco, CA; Zuckerberg San Francisco General Hospital, San Francisco, CA.
Graham L HallChildren's Lung Health, Wal-yan Respiratory Research Centre, Telethon Kids Institute and School of Allied Health, Curtin University, Perth, WA, Australia.
Meredith C McCormackJohns Hopkins University, Baltimore, MD.
Sanja StanojevicDalhousie University, Halifax, NS, Canada.
University of California, San Francisco · USDalhousie University · CAJohns Hopkins University · USThe Kids Research Institute Australia · AUUniversity of Arizona · USUniversity of Vermont · US

Funding

SELPLG as a candidate gene in Acute Respiratory Distress SyndromeK08HL141623 · NHLBI · UNIVERSITY OF ARIZONA · PI BIME, CHRISTIAN · 2018 to 2022
$863k
NHLBI NIH HHS K08 HL141623
6 · The paper itself

Abstract

The practice of using race or ethnicity in medicine to explain differences between individuals is being called into question because it may contribute to biased medical care and research that perpetuates health disparities and structural racism. A commonly cited example is the use of race or ethnicity in the interpretation of pulmonary function test (PFT) results, yet the perspectives of practicing pulmonologists and physiologists are missing from this discussion. This discussion has global relevance for increasingly multicultural communities in which the range of values that represent normal lung function is uncertain. We review the underlying sources of differences in lung function, including those that may be captured by race or ethnicity, and demonstrate how the current practice of PFT measurement and interpretation is imperfect in its ability to describe accurately the relationship between function and health outcomes. We summarize the arguments against using race-specific equations as well as address concerns about removing race from the interpretation of PFT results. Further, we outline knowledge gaps and critical questions that need to be answered to change the current approach of including race or ethnicity in PFT results interpretation thoughtfully. Finally, we propose changes in interpretation strategies and future research to reduce health disparities.

Indexed as

EthnicityHealth Status DisparitiesLungRacial GroupsRespiratory Function TestsAsian PeopleBlack PeopleHumansLung DiseasesReference ValuesSpirometryWhite Peoplepulmonary function testrace or ethnicityracial disparitiesreference equations

Identifiers

PMID34437887
PMCPMC8783030
OpenAlexW3195226059

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.