Evidence map›Paper›PMID 34437845›Full record

ArticleNeuron2021

Enhancing motor learning by increasing the stability of newly formed dendritic spines in the motor cortex.

Eddy Albarran, Aram Raissi, Omar Jáidar, Carla J Shatz, Jun B Ding

Open access · greenAbstract read
In one paragraph

Article in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 56 citations in OpenAlex.

  1. Article
  2. Learning Shapes the Energy Cost of Neural Tasks.bioRxiv : the preprint server for biology · 2026
    Article
  3. The neuroimmune system and cognition.Nature immunology · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. C4d, a high-affinity LilrB2 ligand, is elevated in Alzheimer's disease and mediates synapse pruning.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Article
  10. [Research Progress on the Mechanisms of Visual Cortical Plasticity].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
    Review
  11. Article
  12. Intergenerational Effects of Stress - A Focus on Learning and Memory.Current topics in behavioral neurosciences · 2025
    Review
  13. Review
  14. Review
  15. Synaptic correlates of the corticocortical circuit in motor learning.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Article
  16. Article
  17. Immune receptors and aging brain.Bioscience reports · 2024
    Review
  18. Activity-Dependent Stabilization of Nascent Dendritic Spines Requires Nonenzymatic CaMKIIα Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  19. Layer 5 Intratelencephalic Neurons in the Motor Cortex Stably Encode Skilled Movement.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Eddy AlbarranNeurosciences Graduate Program, Stanford University, Stanford, CA 94305, USA.
Aram RaissiDepartment of Biology, Stanford University, Stanford, CA 94305, USA.
Omar JáidarDepartment of Neurosurgery, Stanford University, Stanford, CA 94305, USA; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA.
Carla J ShatzDepartment of Biology, Stanford University, Stanford, CA 94305, USA; Department of Neurobiology, Stanford University, Stanford, CA 94305, USA; Stanford Bio-X, Stanford University, Stanford, CA 94305, USA. Electronic address: cshatz@stanford.edu.
Jun B DingDepartment of Neurosurgery, Stanford University, Stanford, CA 94305, USA; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA; Stanford Bio-X, Stanford University, Stanford, CA 94305, USA. Electronic address: dingjun@stanford.edu.
Stanford University · USStanford Medicine · US

Funding

FETAL AND POSTNATAL DEVELOPMENT OF VISUAL CONNECTIONSR01EY002858 · NEI · STANFORD UNIVERSITY · PI SHATZ, CARLA J · 1985 to 2020
$9.9M
Dopamine modulation of synaptic plasticity and integration in the striatumR01NS091144 · NINDS · STANFORD UNIVERSITY · PI Jun Ding · 2015 to 2026
$4.2M
Innate immune signaling at the synapse in development and pathological Alzheimer’s diseaseR01AG065206 · NIA · STANFORD UNIVERSITY · PI SHATZ, CARLA J · 2020 to 2024
$2.0M
FETAL AND POSTNATAL DEVELOPMENT OF VISUAL CONNECTIONSR37EY002858 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI SHATZ, CARLA J · 1992 to 2001
$689k
Howard Hughes Medical InstituteNEI NIH HHS R01 EY002858NEI NIH HHS R37 EY002858NIA NIH HHS R01 AG065206NINDS NIH HHS R01 NS091144
6 · The paper itself

Abstract

Dendritic spine dynamics are thought to be substrates for motor learning and memory, and altered spine dynamics often lead to impaired performance. Here, we describe an exception to this rule by studying mice lacking paired immunoglobulin receptor B (PirB

Indexed as

Dendritic SpinesAnimalsLearningMiceMice, KnockoutMotor CortexMotor SkillsNeuronal PlasticityPyramidal CellsReceptors, ImmunologicReceptors, N-Methyl-D-AspartatePirb protein, mouseReceptors, ImmunologicReceptors, N-Methyl-D-Aspartatedendritic spinesmotor learningNMDARPirBsynaptic plasticity

Identifiers

PMID34437845
PMCPMC8542616
OpenAlexW3194665693

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.