Evidence map›Paper›PMID 34437807›Full record

ArticleACS biomaterials science & engineering2021

Rat Calvarial Bone Regeneration by 3D-Printed β-Tricalcium Phosphate Incorporating MicroRNA-200c.

Matthew T Remy, Adil Akkouch, Li He, Steven Eliason, Mason E Sweat, Tadkamol Krongbaramee, Fan Fei, Fang Qian, Brad A Amendt, Xuan Song and 1 more

Abstract read
In one paragraph

Article in ACS biomaterials science & engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Exploring microRNAs in craniofacial regenerative medicine.Biochemical Society transactions · 2023
    Review
  11. Article
  12. Plasmid encodingNanomedicine (London, England) · 2022
    Article
  13. Review
  14. Review
  15. MicroRNA-loaded biomaterials for osteogenesis.Frontiers in bioengineering and biotechnology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Matthew T RemyIowa Institute for Oral Health Research, College of Dentistry, The University of Iowa, Iowa City, Iowa 52242, United States.
Adil AkkouchIowa Institute for Oral Health Research, College of Dentistry, The University of Iowa, Iowa City, Iowa 52242, United States.
Li HeDepartment of Industrial and Systems Engineering, College of Engineering, The University of Iowa, Iowa City, Iowa 52242, United States.
Steven EliasonDepartment of Anatomy and Cell Biology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, United States.
Mason E SweatDepartment of Industrial and Systems Engineering, College of Engineering, The University of Iowa, Iowa City, Iowa 52242, United States.
Tadkamol KrongbarameeIowa Institute for Oral Health Research, College of Dentistry, The University of Iowa, Iowa City, Iowa 52242, United States.
Fan FeiDepartment of Industrial and Systems Engineering, College of Engineering, The University of Iowa, Iowa City, Iowa 52242, United States.
Fang QianIowa Institute for Oral Health Research, College of Dentistry, The University of Iowa, Iowa City, Iowa 52242, United States.
Brad A AmendtIowa Institute for Oral Health Research, College of Dentistry, The University of Iowa, Iowa City, Iowa 52242, United States.
Xuan SongDepartment of Industrial and Systems Engineering, College of Engineering, The University of Iowa, Iowa City, Iowa 52242, United States.ORCID 0000-0002-7353-4252
Liu HongIowa Institute for Oral Health Research, College of Dentistry, The University of Iowa, Iowa City, Iowa 52242, United States.ORCID 0000-0003-0308-5049

Funding

University of Iowa Institutional Training Program in Oral Health ResearchT90DE023520 · NIDCR · UNIVERSITY OF IOWA · PI STEVEN M. LEVY · 2013 to 2026
$5.6M
Co-opting Lef-1 and miR-26b activities to regulate dental stem cells and their progenyR01DE028527 · NIDCR · UNIVERSITY OF IOWA · PI AMENDT, BRAD A, CAO, HUOJUN · 2020 to 2024
$2.1M
Oral and Craniofacial Bone Regeneration using MicroRNA ModulationR01DE026433 · NIDCR · UNIVERSITY OF IOWA · PI AMENDT, BRAD A, HONG, LIU · 2017 to 2021
$1.8M
A microRNA-based Approach for Periodontitis-associated Bone LossR21DE024799 · NIDCR · UNIVERSITY OF IOWA · PI HONG, LIU · 2015 to 2016
$417k
A microRNA-based Approach for Bone RegenerationR21DE025328 · NIDCR · UNIVERSITY OF IOWA · PI HONG, LIU · 2016 to 2017
$410k
Hybrid 3D bioprinting of bone using microRNA-based bioinkR03EB025873 · NIBIB · UNIVERSITY OF IOWA · PI AMENDT, BRAD A · 2018 to 2019
$153k
Bone Regeneration Induced by the Sustained Release of Osteoinductive microRNAs from 3D-printed ConstructsF31DE031153 · NIDCR · UNIVERSITY OF IOWA · PI REMY, MATTHEW T · 2021 to 2022
$76k
NIBIB NIH HHS R03 EB025873NIDCR NIH HHS F31 DE031153NIDCR NIH HHS R01 DE026433NIDCR NIH HHS R01 DE028527NIDCR NIH HHS R21 DE024799NIDCR NIH HHS R21 DE025328NIDCR NIH HHS T90 DE023520
6 · The paper itself

Abstract

Advanced fabrication methods for bone grafts designed to match defect sites that combine biodegradable, osteoconductive materials with potent, osteoinductive biologics would significantly impact the clinical treatment of large bone defects. In this study, we engineered synthetic bone grafts using a hybrid approach that combined three-dimensional (3D-)printed biodegradable, osteoconductive β-tricalcium phosphate (β-TCP) with osteoinductive microRNA(miR)-200c. 3D-printed β-TCP scaffolds were fabricated utilizing a suspension-enclosing projection-stereolithography (SEPS) process to produce constructs with reproducible microarchitectures that enhanced the osteoconductive properties of β-TCP. Collagen coating on 3D-printed β-TCP scaffolds slowed the release of plasmid DNA encoding

Indexed as

MicroRNAsOsteogenesisAnimalsBone RegenerationCalcium PhosphatesPrinting, Three-DimensionalRatsTissue Scaffoldsbeta-tricalcium phosphateCalcium PhosphatesMicroRNAs3D printingbone regenerationcalvarial defectmiR-200cβ-TCP

Identifiers

PMID34437807
PMCPMC8441974

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.