Evidence map›Paper›PMID 34437596›Full record

Trial reportPloS one2021

Effects of intense pulsed light treatment on tear cytokines and clinical outcomes in meibomian gland dysfunction.

Qian Li, Junxiu Liu, Cheng Liu, Junfeng Piao, Wei Yang, Ningyu An, Jinyan Zhu

Registry-linked trialOpen access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06269237 (Point of Care Test of LTA Level in Tear Fluid, Measured With a POCT Test, in DE Patients Following IPL Treatment), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06269237 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Point of Care Test of LTA Level in Tear Fluid, Measured With a POCT Test, in DE Patients Following IPL Treatment

TypeinterventionalSponsorHe Eye HospitalRan2024 to 2024Enrolled30ConditionsDry EyeArmsM22, sham M22
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Qian LiDepartment of Ophthalmology, Ningxia Eye Hospital, Peoples' Hospital of Ningxia Hui Autonomous Region, Ningxia Clinical Research Center on Disease of Blindness in Eye, First Affiliated Hospital of Northwest University for Nationalities, Yinchuan, Ningxia, China.ORCID 0000-0003-3525-0360
Junxiu LiuDepartment of Ophthalmology, Ningxia Eye Hospital, Peoples' Hospital of Ningxia Hui Autonomous Region, Ningxia Clinical Research Center on Disease of Blindness in Eye, First Affiliated Hospital of Northwest University for Nationalities, Yinchuan, Ningxia, China.
Cheng LiuMedical Sci-Tech Research Center of Ningxia Medical University, Yinchuan, Ningxia, China.
Junfeng PiaoDepartment of Ophthalmology, Ningxia Eye Hospital, Peoples' Hospital of Ningxia Hui Autonomous Region, Ningxia Clinical Research Center on Disease of Blindness in Eye, First Affiliated Hospital of Northwest University for Nationalities, Yinchuan, Ningxia, China.
Wei YangDepartment of Ophthalmology, Ningxia Eye Hospital, Peoples' Hospital of Ningxia Hui Autonomous Region, Ningxia Clinical Research Center on Disease of Blindness in Eye, First Affiliated Hospital of Northwest University for Nationalities, Yinchuan, Ningxia, China.
Ningyu AnDepartment of Ophthalmology, Ningxia Eye Hospital, Peoples' Hospital of Ningxia Hui Autonomous Region, Ningxia Clinical Research Center on Disease of Blindness in Eye, First Affiliated Hospital of Northwest University for Nationalities, Yinchuan, Ningxia, China.
Jinyan ZhuDepartment of Ophthalmology, Ningxia Eye Hospital, Peoples' Hospital of Ningxia Hui Autonomous Region, Ningxia Clinical Research Center on Disease of Blindness in Eye, First Affiliated Hospital of Northwest University for Nationalities, Yinchuan, Ningxia, China.
Northwest Minzu University · CNNingxia Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Meibomian gland dysfunction (MGD) has become a prevalent ocular surface disorder. Its pathogenesis is regarded as a self-perpetuating inflammatory vicious circle. Intense Pulsed Light (IPL) treatment was recently applied to improve the meibomian gland function and reduce symptoms of MGD. However, studies investigating the change of specific inflammatory cytokines during IPL treatment remained sparse. To further figure out how IPL treatment modulates the inflammatory cytokines in tears of MGD, we therefore performed a cross-sectional study and enrolled 32 patients from March 2019 to December 2020. The patients received 3 sessions of IPL treatment (10 to 16 J/cm2) at 4-week interval. The signs and symptoms of MGD were evaluated by ocular surface disease index (OSDI), tear film breakup time (TBUT), and meibomian gland yield secretion score (MGYSS). The clinical evaluators and tear samples were analyzed at baseline and at each IPL treatment session. Concentrations of (chemokine ligand) CXCL1, (C-C motif chemokine) CCL11, (tumor necrosis factor) TNF-α, (interferon) IFN-γ, (interleukin) IL-2, IL-6 and (tissue inhibitor of metalloproteinase) TIMP-1were measured by Quantibody Human Dry Eye Disease Array1. OSDI significantly decreased after IPL treatment compared with baseline. TBUT and MGYSS increased consecutively during treatment. CXCL1, CCL11, TNF-α, IFN-γ, IL-2, IL-6 presented significantly decrease and TIMP-1 showed significantly increase from the pretreatment baseline. The changed concentrations of TNF-α, IFN-γ, IL-2, TIMP-1 correlated with TBUT, the changed values of CXCL1, TNF-α, IFN-γ, CCL11, IL-2, IL-6, TIMP-1 correlated with MGYSS, and the changed concentrations of CXCL1, IFN-γ, CCL11, IL-2, IL-6 correlated with TIMP-1. The data supported IPL treatment could significantly relieve both signs and symptoms of MGD. The therapeutic effect of IPL treatment may originate from regulation of inflammatory cytokines including CXCL1, TNF-α, IFN-γ, CCL11, IL-2, IL-6, and TIMP-1.

Indexed as

Intense Pulsed Light TherapyAdultAgedCytokinesFemaleHumansMaleMeibomian Gland DysfunctionMiddle AgedTearsTreatment OutcomeCytokines

Identifiers

PMID34437596
PMCPMC8389452
OpenAlexW3194475863

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.