ReviewPLoS neglected tropical diseases2021
Understanding the transmission of Mycobacterium ulcerans: A step towards controlling Buruli ulcer.
Review in PLoS neglected tropical diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Transmission models of Mycobacterium ulcerans: A systematic review.PLoS neglected tropical diseases · 2025Pooled it
- Biological, Environmental, and Social Determinants of Buruli Ulcer in Africa: Their Interplay Across Disease Severity and Patient Outcome.Public health challenges · 2026Review
- Canonical fact versus hypothesis testing to decipher transmission of non-tuberculous and tuberculous mycobacteria: a comparative review.Clinical microbiology reviews · 2025Review
- Analysis of Agro-Environmental and Geo-Climatic Factors Influencing Buruli Ulcer in the Kimpese Health Zone in Kongo Central, Democratic Republic of Congo.Public health challenges · 2025Article
- Review
- Buruli ulcer in Australia: Evidence for a new endemic focus at Batemans Bay, New South Wales.PLoS neglected tropical diseases · 2024Article
- Experimental infection of ringtail possums (Pseudocheirus peregrinus) with Mycobacterium ulcerans, the agent of Buruli ulcer.Scientific reports · 2024Article
- A low-cost and versatile paramagnetic bead DNA extraction method forApplied and environmental microbiology · 2024Article
- Evaluation of an electricity-independent method for IS2404 Loop-mediated isothermal amplification (LAMP) diagnosis of Buruli ulcer in resource-limited settings.PLoS neglected tropical diseases · 2024Article
- Activation of host nucleic acid sensors byCritical reviews in microbiology · 2024Review
- Mosquitoes provide a transmission route between possums and humans for Buruli ulcer in southeastern Australia.Nature microbiology · 2024Article
- Review
- Comprehensive Case-Control Study of Protective and Risk Factors for Buruli Ulcer, Southeastern Australia.Emerging infectious diseases · 2023Article
- Recent Advances in the Management Strategies for Buruli Ulcers.Pathogens (Basel, Switzerland) · 2023Review
- The oral repellent - science fiction or common sense? Insects, vector-borne diseases, failing strategies, and a bold proposition.Tropical diseases, travel medicine and vaccines · 2023Review
- Perceived water-related risk factors of Buruli ulcer in two villages of south-central Côte d'Ivoire.PLoS neglected tropical diseases · 2022Article
- Enhancing research integration to improve One Health actions: learning lessons from neglected tropical diseases experiences.BMJ global health · 2022Article
- Therapeutic efficacy of rifalazil (KRM-1648) in a M. ulcerans-induced Buruli ulcer mouse model.PloS one · 2022Article
- A combined field study of Buruli ulcer disease in southeast Benin proposing preventive strategies based on epidemiological, geographic, behavioural and environmental analyses.PLOS global public health · 2022Article
- Environmental Persistence of the World's Most Burdensome Infectious and Parasitic Diseases.Frontiers in public health · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mycobacterium ulcerans is the causative agent of Buruli ulcer, a rare but chronic debilitating skin and soft tissue disease found predominantly in West Africa and Southeast Australia. While a moderate body of research has examined the distribution of M. ulcerans, the specific route(s) of transmission of this bacterium remain unknown, hindering control efforts. M. ulcerans is considered an environmental pathogen given it is associated with lentic ecosystems and human-to-human spread is negligible. However, the pathogen is also carried by various mammals and invertebrates, which may serve as key reservoirs and mechanical vectors, respectively. Here, we examine and review recent evidence from these endemic regions on potential transmission pathways, noting differences in findings between Africa and Australia, and summarising the risk and protective factors associated with Buruli ulcer transmission. We also discuss evidence suggesting that environmental disturbance and human population changes precede outbreaks. We note five key research priorities, including adoption of One Health frameworks, to resolve transmission pathways and inform control strategies to reduce the spread of Buruli ulcer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.