ArticlePLoS genetics2021
The impact of age on genetic risk for common diseases.
Article in PLoS genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
69 citing papers in PubMed, 5 syntheses or guidelines pooled it, 106 citations in OpenAlex.
- Methodological approaches, challenges, and opportunities in the application of Mendelian randomisation to lifecourse epidemiology: A systematic literature review.European journal of epidemiology · 2024Pooled it
- Pooled it
- Detailed stratified GWAS analysis for severe COVID-19 in four European populations.Human molecular genetics · 2022Pooled it
- Association of Genetic Predisposition and Physical Activity With Risk of Gestational Diabetes in Nulliparous Women.JAMA network open · 2022Pooled it
- Genome-wide pleiotropy analysis identifies novel blood pressure variants and improves its polygenic risk scores.Genetic epidemiology · 2022Pooled it
- FA-MFMR: a multivariable functional Mendelian randomization method that accounts for correlated longitudinal exposures via factor augmentation.Bioinformatics (Oxford, England) · 2026Article
- Hiding in plain sight: uncovering the genetic basis of complex phenotypes through low-risk groups.Genetics · 2026Article
- Evaluating a Genome-Wide Polygenic Score for Handgrip Strength and Its Interplay with Leisure-Time Physical Activity Across the IGEMS Twin Cohorts.Medicine and science in sports and exercise · 2026Article
- Chronotype and All-Cause Mortality in US Middle-Aged and Older Adults: Results From the NHANES.Journal of sleep research · 2026Article
- Who benefits more from an improved social health insurance? Evidence from supplementary high-cost illness insurance in China.BMC health services research · 2026Article
- Genetic susceptibility to depressive symptoms in middle-aged to older Americans: time-varying effects and effect modification by early psychosocial factors.Social psychiatry and psychiatric epidemiology · 2026Article
- Causal inference in psychiatric research: how to critically evaluate and interpret mendelian randomization studies.Molecular psychiatry · 2026Review
- Genetic Risk and Resilience for Schizophrenia Stratified by Perinatal Gene Expression Predict Adult Cognitive Performance.bioRxiv : the preprint server for biology · 2026Article
- Quantifying the utility of type 2 diabetes polygenic risk score for predicting incident diabetes: an analysis of large US-based cohort studies.BMC medical genomics · 2026Article
- Impact of high-density lipoprotein cholesterol on cardiovascular diseases and all-cause mortality: a large-scale cohort study in Korea.Scientific reports · 2026Article
- CalPred yields calibrated intervals for polygenic risk prediction.medRxiv : the preprint server for health sciences · 2026Article
- An evaluation of age-varying genetic effects underlying body-mass index and blood pressure in the UK Biobank.PLoS genetics · 2026Article
- Clinical use of polygenic risk scores: current status, barriers and future directions.Nature reviews. Genetics · 2026Review
- Article
- Partitioned polygenic scores show mechanistic heterogeneity in type 2 diabetes and hypertension comorbidity.Nature communications · 2026Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Inherited genetic variation contributes to individual risk for many complex diseases and is increasingly being used for predictive patient stratification. Previous work has shown that genetic factors are not equally relevant to human traits across age and other contexts, though the reasons for such variation are not clear. Here, we introduce methods to infer the form of the longitudinal relationship between genetic relative risk for disease and age and to test whether all genetic risk factors behave similarly. We use a proportional hazards model within an interval-based censoring methodology to estimate age-varying individual variant contributions to genetic relative risk for 24 common diseases within the British ancestry subset of UK Biobank, applying a Bayesian clustering approach to group variants by their relative risk profile over age and permutation tests for age dependency and multiplicity of profiles. We find evidence for age-varying relative risk profiles in nine diseases, including hypertension, skin cancer, atherosclerotic heart disease, hypothyroidism and calculus of gallbladder, several of which show evidence, albeit weak, for multiple distinct profiles of genetic relative risk. The predominant pattern shows genetic risk factors having the greatest relative impact on risk of early disease, with a monotonic decrease over time, at least for the majority of variants, although the magnitude and form of the decrease varies among diseases. As a consequence, for diseases where genetic relative risk decreases over age, genetic risk factors have stronger explanatory power among younger populations, compared to older ones. We show that these patterns cannot be explained by a simple model involving the presence of unobserved covariates such as environmental factors. We discuss possible models that can explain our observations and the implications for genetic risk prediction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.