Evidence map›Paper›PMID 34437528›Full record

ReviewPLoS computational biology2021

Review of machine learning methods for RNA secondary structure prediction.

Qi Zhao, Zheng Zhao, Xiaoya Fan, Zhengwei Yuan, Qian Mao, Yudong Yao

Abstract readReview
In one paragraph

Review in PLoS computational biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

  1. Article
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  4. Computational Ligand-Binding Site Prediction.Advances in experimental medicine and biology · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. StructRMDB: A database of RNA modification sites that affect RNA secondary structure.Computational and structural biotechnology journal · 2025
    Article
  17. Transformers in RNA structure prediction: A review.Computational and structural biotechnology journal · 2025
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qi ZhaoCollege of Medicine and Biological Information Engineering, Northeastern University, Shenyang, Liaoning, China.ORCID 0000-0002-7981-9478
Zheng ZhaoSchool of Information Science and Technology, Dalian Maritime University, Dalian, Liaoning, China.ORCID 0000-0002-4214-8164
Xiaoya FanSchool of Software, Key Laboratory for Ubiquitous Network and Service Software of Liaoning Province, Dalian University of Technology, Dalian, Liaoning, China.ORCID 0000-0002-5002-6968
Zhengwei YuanKey Laboratory of Health Ministry for Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.ORCID 0000-0003-0967-9462
Qian MaoCollege of Light Industry, Liaoning University, Shenyang, Liaoning, China.
Yudong YaoDepartment of Electrical and Computer Engineering, Stevens Institute of Technology, Hoboken, New Jersey, United States of America.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Secondary structure plays an important role in determining the function of noncoding RNAs. Hence, identifying RNA secondary structures is of great value to research. Computational prediction is a mainstream approach for predicting RNA secondary structure. Unfortunately, even though new methods have been proposed over the past 40 years, the performance of computational prediction methods has stagnated in the last decade. Recently, with the increasing availability of RNA structure data, new methods based on machine learning (ML) technologies, especially deep learning, have alleviated the issue. In this review, we provide a comprehensive overview of RNA secondary structure prediction methods based on ML technologies and a tabularized summary of the most important methods in this field. The current pending challenges in the field of RNA secondary structure prediction and future trends are also discussed.

Indexed as

Machine LearningNucleic Acid ConformationComputational BiologyRNARNA

Identifiers

PMID34437528
PMCPMC8389396

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.