Evidence map›Paper›PMID 34437509›Full record

ArticleToxics2021

First Evidence of In Vitro Effects of C6O4-A Substitute of PFOA-On Haemocytes of the Clam

Jacopo Fabrello, Francesca Targhetta, Maria Ciscato, Davide Asnicar, Ilaria Bernardini, Massimo Milan, Tomaso Patarnello, Maria Gabriella Marin, Valerio Matozzo

Abstract read
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In one paragraph

Article in Toxics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jacopo FabrelloDepartment of Biology, University of Padova, Via Ugo Bassi 58/B, 35131 Padova, Italy.
Francesca TarghettaDepartment of Biology, University of Padova, Via Ugo Bassi 58/B, 35131 Padova, Italy.
Maria CiscatoDepartment of Biology, University of Padova, Via Ugo Bassi 58/B, 35131 Padova, Italy.
Davide AsnicarDepartment of Biology, University of Padova, Via Ugo Bassi 58/B, 35131 Padova, Italy.ORCID 0000-0002-2066-3659
Ilaria BernardiniDepartment of Comparative Biomedicine and Food Science, University of Padova, Viale dell'Università 16, 35020 Legnaro, Italy.ORCID 0000-0002-1391-0615
Massimo MilanDepartment of Comparative Biomedicine and Food Science, University of Padova, Viale dell'Università 16, 35020 Legnaro, Italy.ORCID 0000-0003-0246-9008
Tomaso PatarnelloDepartment of Comparative Biomedicine and Food Science, University of Padova, Viale dell'Università 16, 35020 Legnaro, Italy.
Maria Gabriella MarinDepartment of Biology, University of Padova, Via Ugo Bassi 58/B, 35131 Padova, Italy.ORCID 0000-0002-1479-5428
Valerio MatozzoDepartment of Biology, University of Padova, Via Ugo Bassi 58/B, 35131 Padova, Italy.ORCID 0000-0001-9935-0366

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alternative chemicals to per- and poly-fluoroalkyl substances have recently been introduced in various industrial processes. C6O4 (difluoro{[2,2,4,5-tetrafluoro-5-(trifluoromethoxy)-1,3-dioxolan-4-yl]oxy}acetic acid) is a new surfactant and emulsifier used as a replacement for perfluorooctanoic acid (PFOA). From an ecotoxicological point of view, in vitro assays are useful tools for assessing the negative effects and understanding the mechanisms of action of chemicals at the cellular level. Here, we present the results of an in vitro study in which the effects of C6O4 were evaluated-for the first time-on haemocytes of the clam

Indexed as

bivalveC6O4haemocytein vitro assaysper- and poly-fluoroalkyl substances

Identifiers

PMID34437509
PMCPMC8402315

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.