Evidence map›Paper›PMID 34437491›Full record

ArticleToxics2021

Rutin-Functionalized Multi-Walled Carbon Nanotubes: Molecular Docking, Physicochemistry and Cytotoxicity in Fibroblasts.

Conrado M S Neto, Felipe C Lima, Renata P Morais, Lucas R M de Andrade, Renata de Lima, Marco V Chaud, Matheus M Pereira, Ricardo L C de Albuquerque Júnior, Juliana C Cardoso, Aleksandra Zielińska and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Journal of traditional and complementary medicine · 2025
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Conrado M S NetoInstitute of Technology and Research (ITP), University of Tiradentes (UNIT), Av. Murilo Dantas, 300, Aracaju 49010-390, Brazil.
Felipe C LimaInstitute of Technology and Research (ITP), University of Tiradentes (UNIT), Av. Murilo Dantas, 300, Aracaju 49010-390, Brazil.
Renata P MoraisInstitute of Technology and Research (ITP), University of Tiradentes (UNIT), Av. Murilo Dantas, 300, Aracaju 49010-390, Brazil.ORCID 0000-0002-6341-9365
Lucas R M de AndradeInstitute of Technology and Research (ITP), University of Tiradentes (UNIT), Av. Murilo Dantas, 300, Aracaju 49010-390, Brazil.
Renata de LimaSchool of Bioprocess Engineering and Biotechnology, Sorocaba University, Rodovia Raposo Tavares km 92, Sorocaba 18023-000, São Paulo, Brazil.
Marco V ChaudSchool of Bioprocess Engineering and Biotechnology, Sorocaba University, Rodovia Raposo Tavares km 92, Sorocaba 18023-000, São Paulo, Brazil.ORCID 0000-0003-3618-8415
Matheus M PereiraDepartment of Chemistry, CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal.ORCID 0000-0003-3524-6900
Ricardo L C de Albuquerque JúniorInstitute of Technology and Research (ITP), University of Tiradentes (UNIT), Av. Murilo Dantas, 300, Aracaju 49010-390, Brazil.
Juliana C CardosoInstitute of Technology and Research (ITP), University of Tiradentes (UNIT), Av. Murilo Dantas, 300, Aracaju 49010-390, Brazil.ORCID 0000-0002-0357-4144
Aleksandra ZielińskaInstitute of Human Genetics, Polish Academy of Sciences Poznan, 60-479 Poznan, Poland.
Eliana B SoutoDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal.
Álvaro S LimaInstitute of Technology and Research (ITP), University of Tiradentes (UNIT), Av. Murilo Dantas, 300, Aracaju 49010-390, Brazil.
Patrícia SeverinoInstitute of Technology and Research (ITP), University of Tiradentes (UNIT), Av. Murilo Dantas, 300, Aracaju 49010-390, Brazil.ORCID 0000-0001-6527-6612
Instituto de Tecnologia e Pesquisa · BRUniversidade de Sorocaba · BRInstitute of Human Genetics · PLUniversity of Aveiro · PTUniversity of Coimbra · PT

Funding

Coordenação Aperfeiçoamento de Pessoal de Nivel Superior (CAPES) and Fundação de Amparo à Pesquisa do Estado de Sergipe (FAPITEC) 88887.159533/2017-00Portuguese Science and Technology Foundation (FCT/MCT) and European Funds (PRODER/COMPETE) UIDB/04469/2020
6 · The paper itself

Abstract

Multi-Walled Carbon Nanotubes (MWCNT) have been functionalized with rutin through three steps (i. reaction step; ii. purification step; iii. drying step) and their physicochemical properties investigated with respect to morphological structure, thermal analysis, Fourier Transform Infrared Spectroscopy (FTIR), and cytotoxicity. The molecular docking suggested the rutin-functionalized MWCNT occurred by hydrogen bonds, which was confirmed by FTIR assays, corroborating the results obtained by thermal analyses. A tubular shape, arranged in a three-dimensional structure, could be observed. Mild cytotoxicity observed in 3T3 fibroblasts suggested a dose-effect relationship after exposure. These findings suggest the formation of aggregates of filamentous structures on the cells favoring the cell penetration.

Indexed as

cytotoxicitydrug deliveryflavonoidsmulti-walled carbon nanotubesrutin

Identifiers

PMID34437491
PMCPMC8402452
OpenAlexW3183998267

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.