Evidence map›Paper›PMID 34437420›Full record

ArticleToxins2021

The Dragon's Paralysing Spell: Evidence of Sodium and Calcium Ion Channel Binding Neurotoxins in Helodermatid and Varanid Lizard Venoms.

James S Dobson, Richard J Harris, Christina N Zdenek, Tam Huynh, Wayne C Hodgson, Frank Bosmans, Rudy Fourmy, Aude Violette, Bryan G Fry

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

James S DobsonVenom Evolution Lab, School of Biological Sciences, University of Queensland, St. Lucia, QLD 4072, Australia.ORCID 0000-0002-4422-0975
Richard J HarrisVenom Evolution Lab, School of Biological Sciences, University of Queensland, St. Lucia, QLD 4072, Australia.ORCID 0000-0002-4412-2275
Christina N ZdenekVenom Evolution Lab, School of Biological Sciences, University of Queensland, St. Lucia, QLD 4072, Australia.ORCID 0000-0002-0385-500X
Tam HuynhDepartment of Pharmacology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
Wayne C HodgsonDepartment of Pharmacology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.ORCID 0000-0002-9919-0144
Frank BosmansDepartment of Basic and Applied Medical Sciences, Ghent University, 9000 Ghent, Belgium.
Rudy FourmyAlphabiotoxine Laboratory sprl, Barberie 15, 7911 Montroeul-au-Bois, Belgium.ORCID 0000-0001-9583-9615
Aude VioletteAlphabiotoxine Laboratory sprl, Barberie 15, 7911 Montroeul-au-Bois, Belgium.
Bryan G FryVenom Evolution Lab, School of Biological Sciences, University of Queensland, St. Lucia, QLD 4072, Australia.ORCID 0000-0001-6661-1283
The University of Queensland · AUAustralian Regenerative Medicine Institute · AUGhent University · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bites from helodermatid lizards can cause pain, paresthesia, paralysis, and tachycardia, as well as other symptoms consistent with neurotoxicity. Furthermore, in vitro studies have shown that

Indexed as

LizardsAnimalsCalcium ChannelsChickensIn Vitro TechniquesMaleNeuromuscular JunctionNeurotoxinsProtein BindingSodium ChannelsVenomsCalcium ChannelsNeurotoxinsSodium ChannelsVenomscalcium channelHelodermaneurotoxicsodium channelToxicoferaVaranusvenom

Identifiers

PMID34437420
PMCPMC8402328
OpenAlexW3189118832

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.