ReviewToxins2021
Chronic Kidney Disease-Associated Pruritus.
Review in Toxins, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Association of pruritus with comorbidities and survival in chronic kidney disease: a narrative review of the pre-difelikefalin era literature.Renal failure · 2026Pooled it
- Difelikefalin in the treatment of hemodialysis patients with pruritus: a systematic review and meta-analysis.Frontiers in pharmacology · 2024Pooled it
- Efficacy and safety of anrikefon in the treatment of diabetic hemodialysis patients with pruritus: a post hoc analysis.BMC nephrology · 2026Trial
- Plasma biomarker profiling suggests renal stress and systemic inflammation in chronic pruritus of unknown origin.JAAD international · 2026Article
- Validity and reliability of the Turkish version of the uremic pruritus in dialysis patients (UP-Dial) scale.International urology and nephrology · 2026Article
- Chronic Kidney Disease-Associated Pruritus in Patients on Home Haemodialysis.Nephrology (Carlton, Vic.) · 2026Article
- Berbamine Attenuates Chronic Kidney Disease-Associated Pruritus by Targeting MRGPRX1/MrgprC11 Signaling.Applied biochemistry and biotechnology · 2026Article
- Associated diagnostic spectrum and stratified characteristics of patients with eosinophilia: a retrospective study.Frontiers in medicine · 2026Article
- Gut microbiota and the kidney-gut-skin axis in chronic kidney disease-associated pruritus: mechanisms and therapeutic implications.Frontiers in cellular and infection microbiology · 2026Review
- Essential oil massage and incident chronic kidney disease-associated pruritus in maintenance hemodialysis patients without baseline pruritus: a prospective non-concurrent before-and-after study.Frontiers in medicine · 2026Article
- Pruritus in Hemodialysis Patients in a Sub-Saharan African Country: Benin-Associated Skin Conditions and Other Factors in 2023 in Three Hemodialysis Centers.Dermatology research and practice · 2026Article
- Association of Chronic Kidney Disease-Associated Pruritus With the Sleep Disturbance, Depression, Pain, Anxiety, and Low Energy/Fatigue Symptom Cluster: A Retrospective Cohort Study.Kidney medicine · 2026Article
- Silver Nanoparticles Attenuate Histamine-Induced Pruritus via Modulation of the Nitric Oxide/iNOS Signaling Pathway in Mice.Nanotechnology, science and applications · 2026Article
- Beyond CKD-Associated Pruritus: Paraneoplastic Itch Revealing CLL/SLL in ESRD: A Case Report.The American journal of case reports · 2025Article
- CKD-Associated Pruritus: A Patient-Centered Approach to Reduce Symptom Burden.Kidney medicine · 2025Review
- Real-world safety of difelikefalin for chronic kidney disease-associated pruritus: initial insights from a European managed access programme.Clinical kidney journal · 2025Article
- Nanoliposome-sericin hydrogel microneedle patches effectively alleviate inflammation and scavenge ROS for the treatment of CKD-aP.Materials today. Bio · 2025Article
- Real-world use of difelikefalin in hemodialysis patients at a large dialysis organization in the United States: a retrospective database study.BMC nephrology · 2025Article
- The impact of low dietary inflammatory index diet on clinical parameters in patients with chronic kidney disease: a retrospective comparative study.BMC nephrology · 2025Article
- Successful Use of Difelikefalin in Severe Chronic Kidney Disease-Associated Pruritus in a Patient With Complex Etiological Contributors: A Case Report.Case reports in nephrology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pruritus is a distressing condition associated with end-stage renal disease (ESRD), advanced chronic kidney disease (CKD), as well as maintenance dialysis and adversely affects the quality of life (QOL) of these patients. It has been reported to range from 20% to as high as 90%. The mechanism of CKD-associated pruritus (CKD-aP) has not been clearly identified, and many theories have been proposed to explain it. Many risk factors have been found to be associated with CKD-aP. The pruritus in CKD presents with diverse clinical features, and there are no set features to diagnose it.The patients with CKD-aP are mainly treated by nephrologists, primary care doctors, and dermatologists. Many treatments have been tried but nothing has been effective. The search of literature included peer-reviewed articles, including clinical trials and scientific reviews. Literature was identified through March 2021, and references of respective articles and only articles published in the English language were included.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.