ArticleScience (New York, N.Y.)2021
Enterically derived high-density lipoprotein restrains liver injury through the portal vein.
Open access · greenAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed, 1 pooled it
20.0field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
118 citing papers in PubMed, 1 synthesis or guideline pooled it, 193 citations in OpenAlex.
- Mechanismbased role of the intestinal microbiota in gestational diabetes mellitus: A systematic review and meta-analysis.Frontiers in immunology · 2022Pooled it
- A low-dose prebiotic fiber supplement reduces lipopolysaccharide-binding protein concentrations in a subgroup of young, healthy adults consuming low-fiber diets.Nutrition research (New York, N.Y.) · 2025Trial
- Inhibiting menin attenuates high-fat diet-induced weight gain by limiting intestinal lipid absorption in mice.The Journal of clinical investigation · 2026Article
- Toll-like receptor 2 impacts small intestinal villus capillarization through epithelial dual oxidase 2.Redox biology · 2026Article
- Regenerative Microbiology: Harnessing Bacterial Antagonism and Spatiotemporal Signaling for Diabetic Wound Repair.Smart medicine · 2026Review
- Gut microbiota in health and disease.Molecular biomedicine · 2026Review
- Microplastics induce liver inflammation in cattle through the rumen microbiota-gut-liver axis.Microbiome · 2026Article
- ABCA1-Mediated Structural Diversity of HDL Subspecies and Their Proposed Roles in Cardioprotection.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- A Gut-Restricted Liver X Receptor Agonist Ameliorates Liver Injury in Experimental Short Bowel Syndrome.Gastroenterology · 2026Article
- Systemic Endotoxemia, Inflammatory Activation, and Lipid Dysregulation in Parkinson's Disease: Evidence from Circulating LPS-Related Biomarkers and Plasma Lipids.International journal of molecular sciences · 2026Article
- The Structural and Functional Journey of Apolipoprotein A-I Through the Human Body.Current atherosclerosis reports · 2026Review
- Apolipoprotein M: Structural insights, functional roles, and therapeutic approaches in vascular disease.The Journal of biological chemistry · 2026Review
- Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differences based on cell type and ApoE isoform.Journal of lipid research · 2026Article
- Aging Triggers an Intestinal Energy Crisis and HDL3 Deficiency Disrupting Gut-Liver Axis Homeostasis.Aging cell · 2026Article
- Investigating the causal roles of cholesterol and triglyceride subfractions across lipoproteins in irritable bowel syndrome: a Mendelian randomization study.Metabolism open · 2026Article
- Proteomic and Lipidomic Atlas of Gut-Associated Lymph and Venous Depots in Female Piglets.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
- Cellular senescence in human liver under normal aging and cancer.Cell genomics · 2026Article
- HDL dysfunction: a role in the pathogenesis of cardiometabolic syndrome in chronic HIV infection?Metabolism: clinical and experimental · 2026Review
- Article
- The Role of Kupffer Cells and Liver Macrophages in the Pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease.Biomedicines · 2026Review
58 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Yong-Hyun HanDepartment of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA. gjrandolph@wustl.edu yhhan1015@kangwon.ac.kr.ORCID 0000-0002-1868-4784
Emily J OnuferDepartment of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-8802-5346
Li-Hao HuangDepartment of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Robert W SprungDepartment of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-2368-8859
W Sean DavidsonDepartment of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45237, USA.ORCID 0000-0003-2756-2989
Rafael S CzepielewskiDepartment of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-2475-3838
Mary WohltmannDepartment of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Mary G Sorci-ThomasDepartment of Medicine, Division of Endocrinology, Pharmacology and Toxicology, and Blood Research Institute, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Brad W WarnerDepartment of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
Gwendalyn J RandolphDepartment of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA. gjrandolph@wustl.edu yhhan1015@kangwon.ac.kr.ORCID 0000-0001-9045-1195
Washington University in St. Louis · USKangwon National University · KRMedical College of Wisconsin · USUniversity of Cincinnati · US
Funding
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0MWU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MWashington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4MWashington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8MWashington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2MWU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1MTrainingP41GM103422 · NIGMS · WASHINGTON UNIVERSITY · PI YARASHESKI, KEVIN E · 2012 to 2019
$12.0MPediatric Gastroenterology Research Training ProgramT32DK077653 · NIDDK · WASHINGTON UNIVERSITY · PI PHILLIP I TARR · 2007 to 2026
$5.8MDIFFERENTIATION AND FUNCTION OF MONOCYTES AND MACROPHAGESR37AI049653 · NIAID · WASHINGTON UNIVERSITY · PI RANDOLPH, GWENDALYN J · 2016 to 2025
$4.3MLymphatic remodeling and transport of dietary fats in short gut syndromeR01DK119147 · NIDDK · WASHINGTON UNIVERSITY · PI Bahaa Elgendy, Ajay K. Jain · 2019 to 2026
$4.0MINTEGRATING CELL & LIPOPROTEIN TRAFFICKING WITH VASCULAR BIOLOGY IN HUMAN IBDDP1DK109668 · NIDDK · WASHINGTON UNIVERSITY · PI RANDOLPH, GWENDALYN J · 2015 to 2019
$3.8MA Biomedical Mass Spectrometry Resource: Ongoing Driving Biomedical ProjectsR24GM136766 · NIGMS · WASHINGTON UNIVERSITY · PI GROSS, MICHAEL L · 2020 to 2022
$2.3MNCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NHLBI NIH HHS L40 HL138908NHLBI NIH HHS R01 HL127649NIAID NIH HHS R37 AI049653NIDDK NIH HHS DP1 DK109668NIDDK NIH HHS DP1 DK126190NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK052574NIDDK NIH HHS P30 DK056341NIDDK NIH HHS R01 DK119147NIDDK NIH HHS R01 DK131136NIDDK NIH HHS T32 DK077653NIGMS NIH HHS P41 GM103422NIGMS NIH HHS R24 GM136766
Abstract
The biogenesis of high-density lipoprotein (HDL) requires apoA1 and the cholesterol transporter ABCA1. Although the liver generates most of the HDL in the blood, HDL synthesis also occurs in the small intestine. Here, we show that intestine-derived HDL traverses the portal vein in the HDL
Indexed as
Acute-Phase ProteinsAdultAnimalsCarrier ProteinsCholesterol, HDLEnterocytesHumansIntestine, SmallKupffer CellsLipopolysaccharide-Binding ProteinLipopolysaccharide ReceptorsLipopolysaccharidesLipoproteins, HDL3LiverLiver CirrhosisLiver DiseasesAcute-Phase ProteinsCarrier ProteinsCholesterol, HDLLipopolysaccharide-Binding ProteinLipopolysaccharide ReceptorsLipopolysaccharidesLipoproteins, HDL3Liver X ReceptorsMembrane GlycoproteinsTlr4 protein, mouseToll-Like Receptor 4
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.