Evidence map›Paper›PMID 34436985›Full record

Observational studyAnnals of the American Thoracic Society2022

Impact of Cystic Fibrosis Transmembrane Conductance Regulator Therapy on Chronic Rhinosinusitis and Health Status: Deep Learning CT Analysis and Patient-reported Outcomes.

Daniel M Beswick, Stephen M Humphries, Connor D Balkissoon, Matthew Strand, Eszter K Vladar, David A Lynch, Jennifer L Taylor-Cousar

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in Annals of the American Thoracic Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Article
  9. Article
  10. Observational
  11. Article
  12. Observational
  13. Elexacaftor-tezacaftor-ivacaftor pharmacokinetics with concurrent tacrolimus administration after lung transplant.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2025
    Observational
  14. Article
  15. Article
  16. Article
  17. Observational
  18. Cystic fibrosis-related chronic rhinosinusitis: the key role of a comprehensive evaluation in the era of highly effective modulator therapy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Daniel M BeswickDepartment of Otolaryngology-Head and Neck Surgery, University of California, Los Angeles, California.ORCID 0000-0001-8612-5442
Stephen M HumphriesDepartment of Radiology.ORCID 0000-0002-5113-4530
Connor D BalkissoonClinical Research Services.
Matthew StrandDivision of Biostatistics, and.
Eszter K VladarDepartment of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, and.
David A LynchDepartment of Radiology.
Jennifer L Taylor-CousarDepartments of Medicine and Pediatrics, National Jewish Health, Denver, Colorado.ORCID 0000-0002-5436-9722
Cancer Research And Biostatistics · USClinical Research Services · DENational Jewish Health · USUniversity of California, Los Angeles · USUniversity of Colorado Denver · US

Funding

Cystic Fibrosis Foundation TAYLOR19A0Marshall and Margherite McComb Foundation
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cystic Fibrosis Transmembrane Conductance RegulatorDeep LearningAdultAminophenolsHumansMutationPatient Reported Outcome MeasuresProspective StudiesQuality of LifeTomography, X-Ray ComputedAminophenolsCystic Fibrosis Transmembrane Conductance RegulatorCFTR modulatorchronic rhinosinusitiscomputed tomographycystic fibrosismachine learning

Identifiers

PMID34436985
PMCPMC8787790
OpenAlexW3196108746

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.