ArticleBioengineered2021
Prognostic role and clinical significance of C-reactive protein-lymphocyte ratio in colorectal cancer.
Article in Bioengineered, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Prognostic significance of the C-reactive protein-to-lymphocyte ratio in patients with cancers.Frontiers in oncology · 2026Pooled it
- The role of lymphocyte-C-reactive protein ratio in the prognosis of gastrointestinal cancer: a systematic review and meta-analysis.Frontiers in oncology · 2024Pooled it
- Prognostic Role of Lymphocyte-C-Reactive Protein Ratio in Colorectal Cancer: A Systematic Review and Meta Analysis.Frontiers in oncology · 2022Pooled it
- Del immune V and microbiome restructuring in colorectal cancer surgery: a randomized double blind placebo controlled trial.Frontiers in cellular and infection microbiology · 2026Trial
- C-reactive protein-to-lymphocyte ratio and perforation in pediatric appendicitis.Surgery today · 2026Article
- Association of the global inflammatory-nutritional index (GINI) with time to next treatment and overall survival in patients with metastatic colorectal cancer receiving third-line therapy: a real-world retrospective study.Journal of gastrointestinal oncology · 2026Article
- Body mass index-based inflammation index is a promising prognostic predictor in older adult cancer patients.BMC geriatrics · 2026Article
- Neutrophil-to-lymphocyte ratio: is it more valuable than CRP in assessing severity of acute diverticulitis at initial presentation? A single-center retrospective cohort study.Irish journal of medical science · 2025Article
- Association between inflammation indicators and albuminuria in US adults: a cross-sectional study.Scientific reports · 2025Article
- The association between composite inflammatory indicators and the clinicopathological characteristics of differentiated thyroid carcinoma.Frontiers in molecular biosciences · 2025Article
- C-reactive protein to lymphocyte ratio combined with clinical features to construct a predictive model for upper gastrointestinal bleeding due to peptic ulcer.Clinics (Sao Paulo, Brazil) · 2025Article
- Associations of C-reactive protein to lymphocyte ratio and metabolic-dysfunction-associated steatotic liver disease: evidence from NHANES 2017-2018.BMC gastroenterology · 2024Article
- An inflammation-based model for identifying severe acute pancreatitis: a single-center retrospective study.BMC gastroenterology · 2024Article
- The relationship between C-reactive protein to lymphocyte ratio and the prevalence of chronic kidney disease in US adults: a cross-sectional study.Frontiers in endocrinology · 2024Article
- The combined detection of hematological indicators is used for the differential diagnosis of colorectal cancer and benign-colorectal lesions.Cancer biomarkers : section A of Disease markers · 2024Article
- MicroRNA-455-3p accelerate malignant progression of tumor by targeting H2AFZ in colorectal cancer.Cell cycle (Georgetown, Tex.) · 2023Article
- Serial Changes in Blood-Cell-Count-Derived and CRP-Derived Inflammatory Indices of COVID-19 Patients.Diagnostics (Basel, Switzerland) · 2023Article
- Prognostic and predictive significance of circulating biomarkers in patients with advanced upper gastrointestinal cancer undergoing systemic chemotherapy.Frontiers in oncology · 2023Article
- C-reactive protein to lymphocyte count ratio is a promising novel marker in hepatitis C infection: the clear hep-c study.Revista da Associacao Medica Brasileira (1992) · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Systemic inflammatory response (SIRS) can be used as a potential prognostic marker in patients with colorectal cancer (CRC). The purpose of this study was to examine the predictive role of the C-reactive protein (CRP)-lymphocyte ratio (CLR) in the prognosis of CRC. We retrospectively analyzed the data of CRC patients who underwent surgery from 2004 to 2019. The clinicopathological characteristics and follow-up records were analyzed. According to a cutoff value of CLR, the patients were divided into the high and low groups. Kaplan-Meier curves and Cox proportional hazards regression model were applied to assess the overall survival (OS). Clinicopathological characteristics analysis showed that gender, age, BMI, lymphocyte count, tumor location, left- and right-sided CRC, differentiation, T stage, M stage, TNM stage, carcinoembryonic antigen (CEA), CLR, CRP, and microsatellite status were found to differ significantly between the high and low CLR groups. Kaplan-Meier curves revealed that the high CLR group had a shorter OS, and the elderly or right-sided CRC patients faced a worse prognosis. Multivariate analysis suggested that age (hazard ratio [HR]:1.011,
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