Evidence map›Paper›PMID 34436902›Full record

ArticleJournal of proteome research2021

Automated Spatially Targeted Optical Microproteomics Investigates Inflammatory Lesions

Bocheng Yin, Laura R Caggiano, Rung-Chi Li, Emily McGowan, Jeffrey W Holmes, Sarah E Ewald

Abstract read
In one paragraph

Article in Journal of proteome research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bocheng YinDepartment of Microbiology, Immunology and Cancer Biology and the Carter Immunology Center, University of Virginia School of Medicine, Charlottesville, Virginia 22903, United States.ORCID 0000-0003-1755-2728
Laura R CaggianoDepartment of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville, Virginia 22903, United States.
Rung-Chi LiDivision of Allergy and Clinical Immunology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia 22903, United States.
Emily McGowanDivision of Allergy and Clinical Immunology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia 22903, United States.
Jeffrey W HolmesDepartment of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville, Virginia 22903, United States.
Sarah E EwaldDepartment of Microbiology, Immunology and Cancer Biology and the Carter Immunology Center, University of Virginia School of Medicine, Charlottesville, Virginia 22903, United States.

Funding

Innate Inflammatory Control of CachexiaR35GM138381 · NIGMS · UNIVERSITY OF VIRGINIA · PI Sarah E. Ewald · 2020 to 2026
$2.9M
Proteomic interrogation of the parasite vacuole using autoSTOMPR21AI156153 · NIAID · UNIVERSITY OF VIRGINIA · PI EWALD, SARAH E. · 2021 to 2022
$444k
Identification of the non-proteolytic mechanism of NLRP1 activationK22AI116727 · NIAID · UNIVERSITY OF VIRGINIA · PI EWALD, SARAH E. · 2016 to 2017
$269k
NIAID NIH HHS K22 AI116727NIAID NIH HHS R21 AI156153NIGMS NIH HHS R35 GM138381
6 · The paper itself

Abstract

Tissue microenvironment properties like blood flow, extracellular matrix, or proximity to immune-infiltrate are important regulators of cell biology. However, methods to study regional protein expression in the native tissue environment are limited. To address this need, we developed a novel approach to visualize, purify, and measure proteins

Indexed as

ProteinsProteomicsAnimalsChromatography, LiquidMass SpectrometryRatsProteinsAutoSTOMPdiscovery proteomicsinflammationproximity biotinylation

Identifiers

PMID34436902
PMCPMC8969901

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.