Evidence map›Paper›PMID 34436757›Full record

ArticleNeurology and therapy2021

Obesity and Poststroke Fatigue: A 2-Year Longitudinal Study.

Mengmeng Gu, Lulu Xiao, Jinjing Wang, Qiankun Cai, Yujing Liu, Pengfei Xu, Yuanlu Liu, Xianjun Huang, Wei Hu, Wen Sun

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Article
  5. Observational
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  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Mengmeng Gu *Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.ORCID http://orcid.org/0000-0001-5158-266X
Lulu Xiao *Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Jinjing Wang *Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Qiankun CaiDepartment of Neurology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
Yujing LiuDepartment of Neurology, Jinling Hospital, Nanjing Medical University, Nanjing, China.
Pengfei XuStroke Center and Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
Yuanlu LiuDepartment of Neurology, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing, China.
Xianjun HuangDepartment of Neurology, Yijishan Hospital, Wannan Medical College, Wuhu, Anhui Province, China.
Wei HuStroke Center and Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China. andinghu@126.com.
Wen SunStroke Center and Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China. sunwen_medneuro@163.com.
Nanjing General Hospital of Nanjing Military Command · CNUniversity of Science and Technology of China · CNFujian Medical University · CNNanjing Medical University · CNWannan Medical College · CN

Funding

fundamental research funds for central universities of the central south university WK9110000056national natural science foundation of china 81501193national natural science foundation of china 81701184natural science foundation of anhui province No. 2008085QH368
6 · The paper itself

Abstract

introductionObesity is associated with fatigue in many diseases, but the correlation between obesity and poststroke fatigue (PSF) is unclear. The study aimed to investigate the relationship between body mass index (BMI) and the occurrence of and recovery from PSF.

methodsWithin 3 days of the onset of ischemic stroke, patients were consecutively recruited. We assessed PSF at admission and at 6, 12, and 24 months with the Fatigue Severity Scale (FSS). Multivariable logistic regression and restricted cubic spline function were used to explore the relationships between baseline BMI and the risk of PSF at different time points. The correlation between baseline BMI and the dynamic changes in the natural logarithm transformation of the FSS (lnFSS) score during the follow-up period was analyzed by the piecewise linear mixed-effects model.

resultsA total of 1026 stroke patients were included. Multivariable analyses indicated that obesity was associated with a decreased risk of early PSF (fatigue diagnosed at baseline) [odds ratio (OR) 0.61, 95% confidence interval (CI) 0.41-0.93] but an increased risk of late PSF (fatigue diagnosed 6 months after the index stroke) (OR 1.63, 95% CI 1.06-2.50 for 6 months; OR 1.87, 95% CI 1.18-2.96 for 12 months; OR 2.11, 95% CI 1.28-3.49 for 24 months). Longitudinal analyses indicated that in the late stage of fatigue, the higher the BMI category, the slower the rate of decrease was for the FSS score.

conclusionObese patients are less likely to develop fatigue in the acute stage of ischemic stroke. However, they are more prone to late fatigue and exhibit a slower decline in the FSS score in the long term.

Indexed as

Body mass indexFatigue Severity ScaleObesityPoststroke fatigue

Identifiers

PMID34436757
PMCPMC8571443
OpenAlexW3195247151

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.