ArticleMetabolic brain disease2021
Benefits of betanin in rotenone-induced Parkinson mice.
Article in Metabolic brain disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 27 citations in OpenAlex.
- Beyond Amyloids: Neuroprotective Potential of Betanin and its Derivatives Against Alpha-Synuclein Aggregates and ROS Overload in Parkinson's Disease.Journal of molecular neuroscience : MN · 2026Article
- Neuroprotective Effects of Betanin in a Mouse Model of Parkinson's Disease: Behavioural and Neurotransmitter Pathway Insights.International journal of molecular sciences · 2025Article
- Exploring anticancer potential of betanin in DMBA-induced oral squamous cell carcinoma: an in silico and experimental study.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Article
- The Neuroprotective Potential of Betalains: A Focused Review.Plants (Basel, Switzerland) · 2025Review
- Neuroprotective effect of gallic acid in mice with rotenone-induced neurodegeneration.Experimental animals · 2024Article
- Beneficial effects of buspirone in endothelin-1 induced stroke cachexia in rats.Molecular and cellular biochemistry · 2023Article
- Combinatorial engineering of betalain biosynthesis pathway in yeast Saccharomyces cerevisiae.Biotechnology for biofuels and bioproducts · 2023Article
- Neuroprotective effects of betanin in mice with cerebral ischemia-reperfusion injury.Experimental animals · 2023Article
- Monoterpenoid Epoxidiol Ameliorates the Pathological Phenotypes of the Rotenone-Induced Parkinson's Disease Model by Alleviating Mitochondrial Dysfunction.International journal of molecular sciences · 2023Article
- Effects of heat degradation of betanin in red beetroot (Beta vulgaris L.) on biological activity and antioxidant capacity.PloS one · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study aimed to investigate betanin's neuroprotective effect in mice with rotenone-induced Parkinson-like motor dysfunction and neurodegeneration. Forty male ICR mice were divided into 4 groups: Sham-veh, Rot-veh, Rot-Bet100 and Rot-Bet200. Rotenone at 2.5 mg/kg/48 h was subcutaneous injected in Rot groups, and betanin at 100 and 200 mg/kg/48 h were given alternately with the rotenone injections in Bet groups for 6 weeks. Motor dysfunctions were evaluated weekly using hanging wire and rotarod tests. Brain oxidative status including malondialdehyde, reduced glutathione, catalase, superoxide dismutase, with neuronal degeneration in the motor cortex, striatum and substantia nigra par compacta were evaluated. The immunohistochemical densities of tyrosine hydroxylase in striatum and in substantia nigra par compacta were also measured. We found that rotenone significantly decreased the time to fall in a hanging wire test after the 4
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