ArticleSleep & breathing = Schlaf & Atmung2022
The relationship between sleep disorders, anxiety, depression, and cognitive function with restless legs syndrome (RLS) in the elderly.
Article in Sleep & breathing = Schlaf & Atmung, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Prevalence of restless legs syndrome in Pakistan: a systematic review and meta-analysis across diverse study populations.BMC neurology · 2026Pooled it
- Migraine and Restless Legs Syndrome: A Meta-Analysis.Journal of sleep research · 2026Pooled it
- Everyday life experiences of family members of individuals with restless legs syndrome: a qualitative interview study.Journal of research in nursing : JRN · 2026Article
- Prevalence and cognitive correlates of sleep problems in Chinese patients with first-episode drug-naïve schizophrenia.BMC psychiatry · 2026Article
- Night-to-Night Sleep Variability Modulates Subjective Sleep Perception in Chronic Insomnia: A Multilevel Analysis.Nature and science of sleep · 2026Article
- Prevalence, risk factors, and clinical impact of restless leg syndrome on uremia patients with hemodialysis.Frontiers in neurology · 2026Article
- Prevalence and correlates of restless leg syndrome in psychiatric outpatients in Lebanon.Scientific reports · 2025Article
- Effect of radiofrequency catheter ablation on cardiac function and quality of life in atrial fibrillation patients.American journal of translational research · 2025Article
- Variant restless legs syndrome masquerading as refractory shoulder pain: a case report and literature review.Frontiers in medicine · 2025Article
- Review
- Association Between Cognitive Function and Emotion, Sleep, Frailty, and Nutrition in Hospitalized Patients.Brain and behavior · 2024Article
- Correlates of Restless Legs Syndrome in Older People.Journal of clinical medicine · 2024Article
- Study on anxiety, depression, and sleep conditions and their interrelations among vocational college students during the COVID-19 pandemic management normalization.Frontiers in public health · 2024Article
- Sleep related movement disorders in the elderly: a review of recent literature.Frontiers in sleep · 2024Review
- Validating Force Sensitive Resistor Strip Sensors for Cardiorespiratory Measurement during Sleep: A Preliminary Study.Sensors (Basel, Switzerland) · 2023Article
- Sleep Quality and Cognitive Function after Stroke: The Mediating Roles of Depression and Anxiety Symptoms.International journal of environmental research and public health · 2023Article
- Correlation between vitamin D and poor sleep status in restless legs syndrome.Frontiers in endocrinology · 2022Article
- Association between thyroid function and disease severity in restless legs syndrome.Frontiers in neurology · 2022Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesRestless legs syndrome (RLS) has a significant effect on sleep and quality of life. Delays in diagnosis and treatment are frequent due to a lack of awareness. In this study, a clinical analysis was performed to examine the relationship between sleep, mood, and cognitive function in RLS.
methodsAccording to the Pittsburgh Sleep Quality Index score (PSQI), patients with RLS were divided into a sleep disorders group (SD, PSQI > 7) and non-sleep disorders group (NSD, PSQI ≤ 7). Healthy controls were selected as a control group matched for age, cultural background, and marital status. We compared differences between the three groups using the Hamilton Anxiety Scale (HAMA), Hamilton Depression (HAMD), Mini-Mental State Examination (MMSE), and Montreal Cognitive Assessment (MoCA). The SD and NSD groups were also assessed with the Restless Leg Syndrome Rating Scale (RLSRS) and the severity of RLS between the two groups was compared. The analysis used t-test, ANOVA, and Pearson correlation.
results(1) Among the 54 RLS patients, 30 people in the control group, 35 patients with sleep disorders (SD, 65%), and 19 patients without sleep disorders (NSD, 35%), there were no significant differences in age, educational level, marital status, or trauma history. (2) The comparison results of the case group (SD and NSD) and the control group showed highly significant differences (P < 0.01) in the PSQI-HAMA-HAMD score but no significant differences between the NSD group, the SD group, and the control group in MMSE score. There was no difference between the NSD group and the control group in the MoCA, but a significant difference (P < 0.05) between the SD group and the control group was found. (3) The comparison between the NSD and the SD groups revealed significant differences in the RLSRS, HAMA, and HAMD scores (P < 0.05), but there were no statistical differences (P > 0.05) between two groups on MMSE and MoCA score. (4) Correlation and regression showed that there was a linear correlation between PSQI scores and RLSRS and HAMD scores in patients with RLS (P < 0.05). The regression equation was PSQI = - 2.393 + 0.494 RLSRS + 0.170 HAMD.
conclusionsRLS patients were prone to sleep disorders, anxiety, and depression. Sleep disorders increased with the severity of the RLS and had some influence on the patient's cognitive function. Sleep disorders were closely related to RLSRS and HAMD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.