Evidence map›Paper›PMID 34436706›Full record

ArticleCardiovascular drugs and therapy2022

Colchicine-Containing Nanoparticles Attenuates Acute Myocardial Infarction Injury by Inhibiting Inflammation.

Li Wang, Yunfan Peng, Lijun Song, Dasheng Xia, Chao Li, Zhuqing Li, Qi Li, Ao Yu, Chengzhi Lu, Yongjian Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Cardiovascular drugs and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.

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  11. Signaling Pathways and Therapeutic Approaches in Post-Myocardial Infarction Fibrosis.Medical science monitor : international medical journal of experimental and clinical research · 2025
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  16. Transcriptomic analysis of Paraoxonase 1 expression in hepatocellular carcinoma and its potential impact on tumor immunity.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Li WangDepartment of Cardiology, Tianjin First Central Hospital, Tianjin, 300192, China.
Yunfan PengResearch Center for Analytical Sciences, College of Chemistry, Nankai University, Tianjin, 300071, China.
Lijun SongDepartment of Digestion, Tianjin First Central Hospital, Tianjin, 300192, China.
Dasheng XiaDepartment of Cardiology, Tianjin First Central Hospital, Tianjin, 300192, China.
Chao LiDepartment of Cardiology, Tianjin First Central Hospital, Tianjin, 300192, China.
Zhuqing LiSchool of Medicine, Nankai University, Tianjin, 300071, China.
Qi LiSchool of Medicine, Nankai University, Tianjin, 300071, China.
Ao YuResearch Center for Analytical Sciences, College of Chemistry, Nankai University, Tianjin, 300071, China.
Chengzhi LuDepartment of Cardiology, Tianjin First Central Hospital, Tianjin, 300192, China. lucz8@126.com.
Yongjian WangKey Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin, 300071, China. yongjian_wang@nankai.edu.cn.ORCID 0000-0003-1035-6070
Nankai University · CNTianjin First Center Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAnti-inflammatory therapy is important for reducing myocardial injury after acute myocardial infarction (MI). New anti-inflammatory drugs and their mechanism are necessary to be explored to improve clinical efficacy. We aimed to improve the efficacy of colchicine on attenuating MI injury by nano-drug delivery systems and to investigate the mechanism of anti-inflammatory.

methodsA colchicine-containing delivery system based on calcium carbonate nanoparticles (ColCaNPs) was synthesized. The protection against MI by ColCaNPs was evaluated using an in vivo rat model established by ligating the left anterior descending coronary artery. Macrophage polarization and the levels of inflammatory cytokines were determined using immunohistochemistry, Western blot, and ELISA analysis.

resultsColCaNP treatment showed about a 45% reduction in myocardial infarct size and attenuating myocardial fibrosis compared with groups without drug intervention after MI. Furthermore, ColCaNPs significantly decreased the levels of CRP, TNF-α, and IL-1β in serum and the expression of proinflammatory cytokine in myocardial tissues after MI (p < 0.05). We also found that ColCaNPs notably restrained pyroptosis and inhibited inflammatory response by modulating on M1/M2 macrophage polarization and suppressing TLR4/NFκB/NLRP3 signal pathway.

conclusionColchicine-containing nanoparticles can protect against MI injury in a clinically relevant rat model by reducing inflammation. In addition, calcium carbonate nanoparticles can increase the cardioprotective effects of colchicine.

Indexed as

Myocardial InfarctionNanoparticlesAnimalsAnti-Inflammatory AgentsCalcium CarbonateColchicineCytokinesDisease Models, AnimalInflammationRatsAnti-Inflammatory AgentsCalcium CarbonateColchicineCytokinesAcute myocardial infarctionColchicineInflammatory responseMacrophage polarizationNanoparticlesPyroptosis

Identifiers

PMID34436706
OpenAlexW3173685459

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.