ArticlePediatric nephrology (Berlin, Germany)2022
Blood pressure variability during pediatric cardiac surgery is associated with acute kidney injury.
Article in Pediatric nephrology (Berlin, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Intraoperative renal and cerebral tissue oxygen saturation measurements to predict postoperative acute kidney injury in pediatric cardiac surgery: a prospective observational study.Journal of clinical monitoring and computing · 2026Observational
- A Single-Center Descriptive Analysis of Interventions for Hypotension in Children: A Retrospective Cohort Study.Paediatric anaesthesia · 2025Observational
- Machine learning prediction and explanation of high intraoperative blood pressure variability for noncardiac surgery using preoperative factors.BMC cardiovascular disorders · 2025Observational
- Relationship between intraoperative blood pressure variability and postoperative acute kidney injury in pediatric cardiac surgery.Pediatric nephrology (Berlin, Germany) · 2025Observational
- Development and Validation of a Nomogram for Predicting Acute Kidney Injury in Pediatric Patients Undergoing Cardiac Surgery.Pediatric cardiology · 2025Article
- Association between intraoperative blood pressure variability and postoperative complications: a narrative review.Frontiers in cardiovascular medicine · 2025Review
- Hypertension, Blood Pressure Variability, and Acute Kidney Injury in Hospitalized Children.Journal of the American Heart Association · 2023Article
- Variability of blood pressure and risk of postoperative acute kidney injury in patients undergoing surgery for acute aortic dissection: A 11-year single-center study.Journal of clinical hypertension (Greenwich, Conn.) · 2023Article
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Authors and funding
8 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundBlood pressure variability (BPV), defined as the degree of variation between discrete blood pressure readings, is associated with poor outcomes in acute care settings. Acute kidney injury (AKI) is a common and serious postoperative complication of cardiac surgery with cardiopulmonary bypass (CPB) in children. No studies have yet assessed the association between intraoperative BPV during cardiac surgery with CPB and the development of AKI in children.
methodsA retrospective chart review of children undergoing cardiac surgery with CPB was performed. Intraoperative BPV was calculated using average real variability (ARV) and standard deviation (SD). Multiple regression models were used to examine the association between BPV and outcomes of AKI, hospital and intensive care unit (PICU) length of stay, and length of mechanical ventilation.
resultsAmong 231 patients (58% males, median age 8.6 months) reviewed, 51.5% developed AKI (47.9% Stage I, 41.2% Stage II, 10.9% Stage III). In adjusted models, systolic and diastolic ARV were associated with development of any stage AKI (OR 1.40, 95% CI 1.08-1.8 and OR 1.4, 95% CI 1.05-1.8, respectively). Greater diastolic SD was associated with longer PICU length of stay (β 0.94, 95% CI 0.62-1.2). When stratified by age, greater systolic ARV and SD were associated with AKI in infants ≤ 12 months, but there was no relationship in children > 12 months.
conclusionsGreater BPV during cardiac surgery with CPB was associated with development of postoperative AKI in infants, suggesting that BPV is a potentially modifiable risk factor for AKI in this high-risk population.
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