Evidence map›Paper›PMID 34436642›Full record

ReviewArchives of toxicology2021

A review of the success and challenges in characterizing human dermal exposure to flame retardants.

Enzo Zini Moreira Silva, Daniel Junqueira Dorta, Danielle Palma de Oliveira, Daniela Morais Leme

Abstract readReview
PubMed Publisher
In one paragraph

Review in Archives of toxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Enzo Zini Moreira SilvaDepartamento de Genética, Setor de Ciências Biológicas, Universidade Federal do Paraná (UFPR), Rua Cel. Francisco H. dos Santos, s/n. Jardim das Américas, Curitiba, PR, 81531-990, Brazil.ORCID http://orcid.org/0000-0002-6003-9527
Daniel Junqueira DortaDepartament of Chemistry, Faculty of Philosophy, Sciences and Letters at Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
Danielle Palma de OliveiraSchool of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
Daniela Morais LemeDepartamento de Genética, Setor de Ciências Biológicas, Universidade Federal do Paraná (UFPR), Rua Cel. Francisco H. dos Santos, s/n. Jardim das Américas, Curitiba, PR, 81531-990, Brazil. daniela.leme@ufpr.br.

Funding

conselho nacional de desenvolvimento científico e tecnológico 465571/2014-0coordenação de aperfeiçoamento de pessoal de nível superior 001fundação de amparo à pesquisa do estado de são paulo 2014/50945-4
6 · The paper itself

Abstract

Since organic flame retardants (FRs) have several industrial applications, they have been largely detected in environmental and biological samples, and humans have been highly exposed to them. Although the effects of oral and inhaled FRs have been well studied, dermal exposure to them has only recently been pointed out as a potential route of human exposure. Consequently, the effects of FRs on the skin and secondary target organs have been poorly investigated. This review article summarizes the main findings regarding dermal exposure to FRs, points the limitation of the published studies, and suggests future perspectives for better understanding of how dermal exposure to FRs impacts the human health. This review lists some gaps that must be filled in future studies, including characterization of the bioavailable fraction and assessment of exposure for new FRs, to establish their physiological significance and to improve the development of 3D dermal tissue for more reliable results to be obtained.

Indexed as

Flame RetardantsSkinEnvironmental ExposureHumansSkin AbsorptionFlame RetardantsDermal uptakeEmerging contaminantsPermeability constantSkin toxicity

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.