ArticleEuropean heart journal2021
Physical activity and fitness in the community: the Framingham Heart Study.
Article in European heart journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- The Effect of Sedentary Behaviour on Cardiorespiratory Fitness: A Systematic Review and Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2024Pooled it
- Rates of compliance and adherence to high-intensity interval training: a systematic review and Meta-analyses.The international journal of behavioral nutrition and physical activity · 2023Pooled it
- Trial
- Wearable Device-Based Intervention for Promoting Patient Physical Activity After Lung Cancer Surgery: A Nonrandomized Clinical Trial.JAMA network open · 2024Trial
- Ambivalence is associated with decreased physical activity and cardiorespiratory fitness among adolescents with critical congenital heart disease.Heart & lung : the journal of critical careTrial
- Dose-Response Associations Between Daily Step Count, Cardiorespiratory Fitness, and Symptoms of Depression, Anxiety, and Stress in University Students.Journal of clinical medicine · 2026Article
- Joint effects of sleep behaviors and physical activity on brain structure and cognitive function.Fundamental research · 2026Article
- Dog Owners Exhibit Better Diet Quality but Similar Physical Activity Compared to Non-Owners: A Case-Control Study.Nutrients · 2025Article
- Human development and gender inequality are associated with cardiorespiratory fitness: A global systematic review of V̇OJournal of sport and health science · 2025Review
- Epidemiology and Cardiovascular Benefits of Physical Activity and Exercise.Circulation research · 2025Review
- Daily Heart Rate per Step: A Wearables Metric Associated With Cardiovascular Disease in a Cross-Sectional Study of theJournal of the American Heart Association · 2025Observational
- Movement behaviors and cardiorespiratory fitness - a cross-sectional compositional data analysis among German adults.BMC sports science, medicine & rehabilitation · 2025Article
- Physical Activity, Sleep, and Risk of Late-Onset Severe Mental Illness: A Prospective Cohort Study From UK Biobank.Schizophrenia bulletin · 2025Article
- The Metabolic Signature of Cardiorespiratory Fitness.Scandinavian journal of medicine & science in sports · 2025Article
- Change in Free-Living Daily Steps does not Affect VOInternational journal of exercise science · 2025Article
- Hepatic Steatosis and Fibrosis, Cardiorespiratory Fitness, and Metabolic Mediators in the Community.Liver international : official journal of the International Association for the Study of the Liver · 2025Article
- Association of moderate-to-vigorous physical activity with reduction of acute exacerbation in COPD patients using a dual ultra-long-acting bronchodilators.Scientific reports · 2024Article
- Clusters of multidimensional exercise response patterns and estimated heart failure risk in the Framingham Heart Study.ESC heart failure · 2024Article
- Joint association of sedentary time and physical activity with abnormal heart rate recovery in young and middle-aged adults.BMC public health · 2024Observational
- Association of Smartwatch-Based Heart Rate and Physical Activity With Cardiorespiratory Fitness Measures in the Community: Cohort Study.Journal of medical Internet research · 2024Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
Abstract
aimsWhile greater physical activity (PA) is associated with improved health outcomes, the direct links between distinct components of PA, their changes over time, and cardiorespiratory fitness are incompletely understood. METHODS AND
resultsMaximum effort cardiopulmonary exercise testing (CPET) and objective PA measures [sedentary time (SED), steps/day, and moderate-vigorous PA (MVPA)] via accelerometers worn for 1 week concurrent with CPET and 7.8 years prior were obtained in 2070 Framingham Heart Study participants [age 54 ± 9 years, 51% women, SED 810 ± 83 min/day, steps/day 7737 ± 3520, MVPA 22.3 ± 20.3 min/day, peak oxygen uptake (VO2) 23.6 ± 6.9 mL/kg/min]. Adjusted for clinical risk factors, increases in steps/day and MVPA and reduced SED between the two assessments were associated with distinct aspects of cardiorespiratory fitness (measured by VO2) during initiation, early-moderate level, peak exercise, and recovery, with the highest effect estimates for MVPA (false discovery rate <5% for all). Findings were largely consistent across categories of age, sex, obesity, and cardiovascular risk. Increases of 17 min of MVPA/day [95% confidence interval (CI) 14-21] or 4312 steps/day (95% CI 3439-5781; ≈54 min at 80 steps/min), or reductions of 249 min of SED per day (95% CI 149-777) between the two exam cycles corresponded to a 5% (1.2 mL/kg/min) higher peak VO2. Individuals with high (above-mean) steps or MVPA demonstrated above average peak VO2 values regardless of whether they had high or low SED.
conclusionsOur findings provide a detailed assessment of relations of different types of PA with multidimensional cardiorespiratory fitness measures and suggest favourable longitudinal changes in PA (and MVPA in particular) are associated with greater objective fitness.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.