Evidence map›Paper›PMID 34436507›Full record

ArticleGenetics and molecular biology2021

Human-SARS-CoV-2 interactome and human genetic diversity: TMPRSS2-rs2070788, associated with severe influenza, and its population genetics caveats in Native Americans.

Fernanda S G Kehdy, Murilo Pita-Oliveira, Mariana M Scudeler, Sabrina Torres-Loureiro, Camila Zolini, Rennan Moreira, Lucas A Michelin, Isabela Alvim, Carolina Silva-Carvalho, Vinicius C Furlan and 14 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genetics and molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 10 institutions in 4 countries.

Fernanda S G KehdyInstituto Oswaldo Cruz, Fundação Oswaldo Cruz, Laboratório de Hanseníase, Rio de Janeiro, RJ, Brazil.
Murilo Pita-OliveiraUniversidade Federal do Triângulo Mineiro, Instituto de Ciências Biológicas e Naturais, Departamento de Patologia, Genética e Evolução, Uberaba, MG, Brazil.
Mariana M ScudelerUniversidade Federal do Triângulo Mineiro, Instituto de Ciências Biológicas e Naturais, Departamento de Patologia, Genética e Evolução, Uberaba, MG, Brazil.
Sabrina Torres-LoureiroUniversidade Federal do Triângulo Mineiro, Instituto de Ciências Biológicas e Naturais, Departamento de Patologia, Genética e Evolução, Uberaba, MG, Brazil.
Camila ZoliniUniversidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Genética, Ecologia e Evolução, Belo Horizonte, MG, Brazil.
Rennan MoreiraUniversidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Genética, Ecologia e Evolução, Belo Horizonte, MG, Brazil.
Lucas A MichelinUniversidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Genética, Ecologia e Evolução, Belo Horizonte, MG, Brazil.
Isabela AlvimUniversidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Genética, Ecologia e Evolução, Belo Horizonte, MG, Brazil.
Carolina Silva-CarvalhoUniversidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Genética, Ecologia e Evolução, Belo Horizonte, MG, Brazil.
Vinicius C FurlanUniversidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Genética, Ecologia e Evolução, Belo Horizonte, MG, Brazil.
Marla M AquinoUniversidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Genética, Ecologia e Evolução, Belo Horizonte, MG, Brazil.
Meddly L SantolallaUniversidad Peruana Cayetano Heredia, School of Public Health and Administration, Emerging Diseases and Climate Change Research Unit, Lima, Peru.
Victor BordaLaboratório Nacional de Computação Científica (LNCC), Laboratório de Bioinformática, Petrópolis, RJ, Brazil.
Giordano B Soares-SouzaUniversidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Genética, Ecologia e Evolução, Belo Horizonte, MG, Brazil.
Luis Jaramillo-ValverdeINBIOMEDIC Research and Technological Center, Lima, Peru.
Andres Vasquez-DominguezINBIOMEDIC Research and Technological Center, Lima, Peru.
Cesar Sanchez NeiraInstituto Nacional de Salud, Lima, Peru.
Renato S AguiarUniversidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Genética, Ecologia e Evolução, Belo Horizonte, MG, Brazil.
Ricardo A VerdugoUniversidad de Chile, Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Genética Humana, Santiago, Chile.
Timothy D O ConnorUniversity of Maryland School of Medicine, Institute for Genome Sciences, Baltimore, United States.
Heinner GuioInstituto Nacional de Salud, Lima, Peru.ORCID http://orcid.org/0000-0003-0078-1188
Eduardo Tarazona-SantosUniversidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Genética, Ecologia e Evolução, Belo Horizonte, MG, Brazil.
Thiago P LealUniversidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Genética, Ecologia e Evolução, Belo Horizonte, MG, Brazil.
Fernanda Rodrigues-SoaresUniversidade Federal do Triângulo Mineiro, Instituto de Ciências Biológicas e Naturais, Departamento de Patologia, Genética e Evolução, Uberaba, MG, Brazil.ORCID http://orcid.org/0000-0002-2559-3223
Universidade Federal de Minas Gerais · BRUniversidade Federal do Triângulo Mineiro · BRUniversidad Tecnológica del Perú · PEFundação Oswaldo Cruz · BRInstituto Nacional de Salud · PELaboratório Nacional de Computação Científica · BRUniversidad de Huánuco · PEUniversidad Peruana Cayetano Heredia · PEUniversity of Chile · CLUniversity of Maryland, Baltimore · US

Funding

Rapid Evolution of Genomic Architecture and Multi-omics TraitsR35HG010692 · NHGRI · UNIVERSITY OF MARYLAND BALTIMORE · PI O'CONNOR, TIMOTHY DAVID · 2019 to 2023
$2.3M
NHGRI NIH HHS R35 HG010692
6 · The paper itself

Abstract

For human/SARS-CoV-2 interactome genes ACE2, TMPRSS2 and BSG, there is a convincing evidence of association in Asians with influenza-induced SARS for TMPRSS2-rs2070788, tag-SNP of the eQTL rs383510. This case illustrates the importance of population genetics and of sequencing data in the design of genetic association studies in different human populations: the high linkage disequilibrium (LD) between rs2070788 and rs383510 is Asian-specific. Leveraging on a combination of genotyping and sequencing data for Native Americans (neglected in genetic studies), we show that while their frequencies of the Asian tag-SNP rs2070788 is, surprisingly, the highest worldwide, it is not in LD with the eQTL rs383510, that therefore, should be directly genotyped in genetic association studies of SARS in populations with Native American ancestry.

Identifiers

PMID34436507
PMCPMC8387978
OpenAlexW3195371203

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.