Evidence map›Paper›PMID 34436500›Full record

ArticleMetabolites2021

Fiber-Rich Barley Increases Butyric Acid-Producing Bacteria in the Human Gut Microbiota.

Shohei Akagawa, Yuko Akagawa, Yoko Nakai, Mitsuru Yamagishi, Sohsaku Yamanouchi, Takahisa Kimata, Kazushige Chino, Taiga Tamiya, Masaki Hashiyada, Atsushi Akane and 2 more

Abstract read
In one paragraph

Article in Metabolites, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Trial
  2. Article
  3. Mechanistic insights intoFood chemistry: X · 2026
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  7. Article
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  12. Article
  13. Article
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  15. Role of the gut microbiota in complications after ischemic stroke.Frontiers in cellular and infection microbiology · 2024
    Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shohei AkagawaDepartment of Pediatrics, Kansai Medical University, 2-5-1 Shinmachi, Hirakata 573-1010, Japan.ORCID 0000-0002-1659-4187
Yuko AkagawaDepartment of Pediatrics, Kansai Medical University, 2-5-1 Shinmachi, Hirakata 573-1010, Japan.ORCID 0000-0002-0344-7778
Yoko NakaiDepartment of Pediatrics, Kansai Medical University, 2-5-1 Shinmachi, Hirakata 573-1010, Japan.
Mitsuru YamagishiDepartment of Pediatrics, Kansai Medical University, 2-5-1 Shinmachi, Hirakata 573-1010, Japan.
Sohsaku YamanouchiDepartment of Pediatrics, Kansai Medical University, 2-5-1 Shinmachi, Hirakata 573-1010, Japan.
Takahisa KimataDepartment of Pediatrics, Kansai Medical University, 2-5-1 Shinmachi, Hirakata 573-1010, Japan.
Kazushige ChinoHealthcare New Business Division, TEIJIN Limited, 3-2-1 Kasumigaseki, Tokyo 100-8585, Japan.
Taiga TamiyaBio Palette Co., Ltd., 1-1 Rokkodai-cho, Kobe 650-0047, Japan.ORCID 0000-0002-8021-4628
Masaki HashiyadaDepartment of Legal Medicine, Kansai Medical University, 2-5-1 Shinmachi, Hirakata 573-1010, Japan.
Atsushi AkaneDepartment of Legal Medicine, Kansai Medical University, 2-5-1 Shinmachi, Hirakata 573-1010, Japan.ORCID 0000-0001-8033-8367
Shoji TsujiDepartment of Pediatrics, Kansai Medical University, 2-5-1 Shinmachi, Hirakata 573-1010, Japan.ORCID 0000-0003-3607-8355
Kazunari KanekoDepartment of Pediatrics, Kansai Medical University, 2-5-1 Shinmachi, Hirakata 573-1010, Japan.ORCID 0000-0002-8215-0832

Funding

Kansai Medical University n/aNipponham Foundation for the Future of Food n/aThe Morinaga Foundation for Health & Nutrition n/a
6 · The paper itself

Abstract

Butyric acid produced in the intestine by butyric acid-producing bacteria (BAPB) is known to suppress excessive inflammatory response and may prevent chronic disease development. We evaluated whether fiber-rich barley intake increases BAPB in the gut and concomitantly butyric acid in feces. Eighteen healthy adults received granola containing functional barley (BARLEYmax

Indexed as

16S rRNA gene sequencingbutyric acid-producing bacteriadietary fibermicrobiotaprebiotics

Identifiers

PMID34436500
PMCPMC8399161

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.