ReviewMetabolites2021
Unravelling Plant Responses to Stress-The Importance of Targeted and Untargeted Metabolomics.
Review in Metabolites, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 102 citations in OpenAlex.
- Metabolic reprogramming in plant defense: linking signaling networks to metabolomics-driven insights.Plant signaling & behavior · 2026Review
- Diurnal Variations in Photochemical Energy Utilization and Osmotic Adjustments in Black Poplar Leaves Under Progressive Water Stress.Plant, cell & environment · 2026Article
- Microbial volatile organic compounds in plant defense: mechanisms, signaling networks, and agricultural applications.World journal of microbiology & biotechnology · 2026Review
- In-source freezing of Trifolium repens leaf tissue to increase spatial resolution and quench stress responses during IR-MALDESI mass spectrometry imaging.Analytical and bioanalytical chemistry · 2026Article
- Seasonality and fruiting converge on megastigmanes to shape foliar metabolic plasticity in Miconia albicans (Swartz) Triana (Melastomataceae).Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Untargeted Metabolomic and Lipidomic Profiles of Gingival Crevicular Fluid in the Context of Periodontitis.Journal of clinical periodontology · 2026Article
- Characterization ofJournal of fungi (Basel, Switzerland) · 2026Article
- Metabolic and Biochemical Responses of Heirloom and Hybrid Tomato (Solanum lycopersicum) Under Flooding, Specialist, and Generalist Insect Herbivory, and their Stress Combination.Journal of chemical ecology · 2026Article
- Metabolic reprogramming and functional trade-offs during domestication of Sechium edule.Scientific reports · 2026Article
- Beyond Resistance Genes: Silencing Susceptibility.International journal of molecular sciences · 2026Review
- Assessment of phenotypic trait plasticity in the oilseed Camelina sativa using integrated early stage abiotic stress and field studies.Plant physiology · 2026Article
- Harnessing endophytes and Multi-Omics for sustainable Colchicine biosynthesis.World journal of microbiology & biotechnology · 2026Review
- Tissue-specific metabolomic profiling reveals cultivar-dependent drought tolerance mechanisms in rice (Oryza sativa L.).BMC plant biology · 2026Article
- The unacknowledged co-author: LLM-mediated reasoning in plant metabolomics and its systematic blind spots.Frontiers in plant science · 2026Article
- A voyage of reprogrammable metabolic bioengineering reshapes plant defense: from editing tools to synthetic systems.Frontiers in plant science · 2026Review
- Metabolomic-based promising technique for fruit-based natural products analysis.Food chemistry: X · 2025Review
- Metabolomic Analysis of Tomato Plants Treated With Garlic Extract,Plant-environment interactions (Hoboken, N.J.) · 2025Article
- Metabolomic and systems biology insights into lead stress tolerance of Pennisetum purpureum bioaugmented with Enterobacter cloacae.Archives of microbiology · 2025Article
- The Role of Omics Technology in Evaluating Plastic Pollution's Effects on Plants: A Comprehensive Review.International journal of molecular sciences · 2025Review
- Plant-pathogen interactions: making the case for multi-omics analysis of complex pathosystems.Stress biology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 6 institutions in 3 countries.
Funding
Abstract
Climate change and an increasing population, present a massive global challenge with respect to environmentally sustainable nutritious food production. Crop yield enhancements, through breeding, are decreasing, whilst agricultural intensification is constrained by emerging, re-emerging, and endemic pests and pathogens, accounting for ~30% of global crop losses, as well as mounting abiotic stress pressures, due to climate change. Metabolomics approaches have previously contributed to our knowledge within the fields of molecular plant pathology and plant-insect interactions. However, these remain incredibly challenging targets, due to the vast diversity in metabolite volatility and polarity, heterogeneous mixtures of pathogen and plant cells, as well as rapid rates of metabolite turn-over. Unravelling the systematic biochemical responses of plants to various individual and combined stresses, involves monitoring signaling compounds, secondary messengers, phytohormones, and defensive and protective chemicals. This demands both targeted and untargeted metabolomics approaches, as well as a range of enzymatic assays, protein assays, and proteomic and transcriptomic technologies. In this review, we focus upon the technical and biological challenges of measuring the metabolome associated with plant stress. We illustrate the challenges, with relevant examples from bacterial and fungal molecular pathologies, plant-insect interactions, and abiotic and combined stress in the environment. We also discuss future prospects from both the perspective of key innovative metabolomic technologies and their deployment in breeding for stress resistance.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.