Evidence map›Paper›PMID 34436473›Full record

ArticleMetabolites2021

Anti-Proliferative Potential of Secondary Metabolites from the Marine Sponge

Kuei-Hung Lai, Bo-Rong Peng, Chun-Han Su, Mohamed El-Shazly, Yi-Long Sun, Ming-Cheng Shih, Yu-Ting Huang, Pei-Tzu Yen, Lung-Shuo Wang, Jui-Hsin Su

Open access · goldAbstract read
In one paragraph

Article in Metabolites, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Capnellenes fromPharmaceuticals (Basel, Switzerland) · 2023
    Article
  3. Marine drugs · 2023
    Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Kuei-Hung LaiPhD Program in Clinical Drug Development of Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0001-7220-6356
Bo-Rong PengNational Museum of Marine Biology & Aquarium, Pingtung 94450, Taiwan.ORCID 0000-0002-4537-1353
Chun-Han SuAgricultural Biotechnology Research Center, Academia Sinica, Taipei 11529, Taiwan.ORCID 0000-0002-9144-8577
Mohamed El-ShazlyDepartment of Pharmaceutical Biology, German University in Cairo, Cairo 11432, Egypt.
Yi-Long SunDepartment of Biological Science & Technology, I-Shou University, Kaohsiung 82445, Taiwan.
Ming-Cheng ShihDepartment of Biological Science & Technology, I-Shou University, Kaohsiung 82445, Taiwan.
Yu-Ting HuangDepartment of Nutrition, I-Shou University, Kaohsiung 82445, Taiwan.
Pei-Tzu YenDepartment of Chinese Medicine, Sin-Lau Hospital, Tainan 70142, Taiwan.
Lung-Shuo WangDepartment of Chinese Medicine, Sin-Lau Hospital, Tainan 70142, Taiwan.
Jui-Hsin SuNational Museum of Marine Biology & Aquarium, Pingtung 94450, Taiwan.
I-Shou University · TWNational Sun Yat-sen University · TWSin-Lau Christian Hospital · TWAgricultural Biotechnology Research Center, Academia Sinica · TWAin Shams University · EGTaipei Medical University Hospital · TW

Funding

Ministry of Education DP2-110-21121-01-N-12-03Ministry of Science and Technology, Taiwan MOST 108-2320-B-291-001-MY3Ministry of Science and Technology, Taiwan MOST 110-2320-B-038-013Ministry of Science and Technology, Taiwan MOST 110-2320-B-038-034Taipei Medical University TMU109-AE1-B15
6 · The paper itself

Abstract

Marine sponges have been recognized as a rich source of potential anti-proliferative metabolites. Currently, there are two sponge-derived anti-cancer agents (a macrolide and a nucleoside) isolated from the Porifera phylum, suggesting the great potential of this sponge as a rich source for anti-neoplastic agents. To search for more bioactive metabolites from this phylum, we examined the EtOAc extract of

Indexed as

4-methylene sterolsanti-proliferationChemGPS-NPmacrolidesnucleosidesTheonella sp.

Identifiers

PMID34436473
PMCPMC8400523
OpenAlexW3188887280

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.