Evidence map›Paper›PMID 34436441›Full record

ArticleMetabolites2021

Respiratory Colonization and Short-Term Temporal Changes in the Urinary Metabolome of Children.

Lilliam Ambroggio, Todd A Florin, Kayla Williamson, Cory Pfefferman, Brandie D Wagner, Larisa Yeomans, Jae Hyun Kim, Heidi Sucharew, Maurizio Macaluso, Richard M Ruddy and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Urine Metabolites of Suspected Community-Acquired Pneumonia.The Journal of infectious diseases · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Lilliam AmbroggioSections of Emergency Medicine and Hospital Medicine, Children's Hospital Colorado & Department of Pediatrics, University of Colorado, Aurora, CO 80045, USA.
Todd A FlorinDivision of Emergency Medicine, Ann and Robert H. Lurie Children's Hospital of Chicago & Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Kayla WilliamsonDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado, Aurora, CO 80045, USA.
Cory PfeffermanDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center & Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
Brandie D WagnerDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado, Aurora, CO 80045, USA.
Larisa YeomansNuclear Magnetic Resonance Metabolomics Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Clinical Pharmacy, College of Pharmacy, Michigan Center for Integrative Research in Critical Care, School of Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Jae Hyun KimNuclear Magnetic Resonance Metabolomics Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Clinical Pharmacy, College of Pharmacy, Michigan Center for Integrative Research in Critical Care, School of Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Heidi SucharewDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center & Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
Maurizio MacalusoDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center & Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
Richard M RuddyDivision of Emergency Medicine, Cincinnati Children's Hospital Medical Center & Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
Samir S ShahDivisions of Hospital Medicine and Infectious Diseases, Cincinnati Children's Hospital Medical Center & Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
Kathleen A StringerNuclear Magnetic Resonance Metabolomics Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Clinical Pharmacy, College of Pharmacy, Michigan Center for Integrative Research in Critical Care, School of Medicine, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-0238-7774
Cincinnati Children's Hospital Medical Center · USUniversity of Michigan · USColorado School of Public Health · USChildren's Hospital Colorado · USNorthwestern University · US

Funding

Translational Metabolomics in Critical CareR35GM136312 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KATHLEEN A STRINGER · 2020 to 2026
$2.8M
L-Carnitine Pharmacometabolomics in Sepsis (CaPS)R01GM111400 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI STRINGER, KATHLEEN A · 2016 to 2019
$1.2M
BIOMARKERS AND RISK STRATIFICATION IN PEDIATRIC COMMUNITY-ACQUIRED PNEUMONIAK23AI121325 · NIAID · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI FLORIN, TODD ADAM · 2016 to 2019
$743k
Metabolomics Evaluation of the Etiology of PneumoniaK01AI125413 · NIAID · UNIVERSITY OF COLORADO DENVER · PI AMBROGGIO, LILLIAM · 2017 to 2021
$641k
National Institute of Allergy and Infectious Diseases K23 AI 121325NIAID NIH HHS K01 AI125413NIAID NIH HHS K23 AI121325NIGMS NIH HHS R01GM111400NIGMS NIH HHS R35 GM136312
6 · The paper itself

Abstract

The human metabolome may vary based on age, over time, and in the presence of viral carriage and bacterial colonization-a common scenario in children. We used nuclear magnetic resonance spectroscopy to identify and quantify urinary metabolites of children without signs or symptoms of respiratory illness. A urine sample and two nasopharyngeal swabs were collected to test for respiratory viral pathogens and colonization by

Indexed as

healthymetabolomenuclear magnetic resonancepediatricrhinovirus/enterovirusStreptococcus pneumoniae

Identifiers

PMID34436441
PMCPMC8400807
OpenAlexW3190108116

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.