ArticleMetabolites2021
Distinct Changes in Gut Microbiota Are Associated with Estradiol-Mediated Protection from Diet-Induced Obesity in Female Mice.
Article in Metabolites, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 22 citations in OpenAlex.
- Research advances on estrogen deficiency leading to depression.Translational neuroscience · 2026Review
- The Role and Mechanism of Estrogen in Perimenopausal Depression.Current neuropharmacology · 2026Review
- Exploring the molecular crosstalk between the sex steroids drospirenone and ethinylestradiol with vaginal lactobacilli.Frontiers in microbiology · 2026Article
- Estradiol Modulates the Sensitivity to Vancomycin ofMicroorganisms · 2025Article
- Identification of Fecal Microbiota and Related Metabolites Associated with Feed Efficiency in DLY Pigs.Animals : an open access journal from MDPI · 2025Article
- Navigating complexities of polymorphic microbiomes in endometrial cancer.NPJ biofilms and microbiomes · 2025Article
- Loss of endothelial TRPC1 aggravates metabolic dysfunction in obesity via disrupting adipose tissue homeostasis.Frontiers in molecular biosciences · 2025Article
- Dietary index for gut microbiota, a novel protective factor for the prevalence of chronic kidney diseases in the adults: insight from NHANES 2007-2018.Frontiers in nutrition · 2025Article
- Effect of time-restricted eating regimen on weight loss is mediated by gut microbiome.iScience · 2024Article
- Gut Biogeography Accentuates Sex-Related Differences in the Murine Microbiome.Microorganisms · 2024Article
- Neurobiology of Pathogen Avoidance and Mate Choice: Current and Future Directions.Animals : an open access journal from MDPI · 2024Review
- Intestinal microbial circadian rhythms drive sex differences in host immunity and metabolism.iScience · 2023Article
- Gut Microbiota and Acylcarnitine Metabolites Connect the Beneficial Association between Estrogen and Lipid Metabolism Disorders in Ovariectomized Mice.Microbiology spectrum · 2023Article
- Estradiol-mediated protection against high-fat diet induced anxiety and obesity is associated with changes in the gut microbiota in female mice.Scientific reports · 2023Article
- Different gender-derived gut microbiota influence stroke outcomes by mitigating inflammation.Journal of neuroinflammation · 2022Article
- Gut Steroids and Microbiota: Effect of Gonadectomy and Sex.Biomolecules · 2022Article
- Differential effects ofFrontiers in endocrinology · 2022Article
- Effects of Electroacupuncture on the Gut Microbiome in Cisplatin-Induced Premature Ovarian Failure Mice.Evidence-based complementary and alternative medicine : eCAM · 2022Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
A decrease in ovarian estrogens in postmenopausal women increases the risk of weight gain, cardiovascular disease, type 2 diabetes, and chronic inflammation. While it is known that gut microbiota regulates energy homeostasis, it is unclear if gut microbiota is associated with estradiol regulation of metabolism. In this study, we tested if estradiol-mediated protection from high-fat diet (HFD)-induced obesity and metabolic changes are associated with longitudinal alterations in gut microbiota in female mice. Ovariectomized adult mice with vehicle or estradiol (E2) implants were fed chow for two weeks and HFD for four weeks. As reported previously, E2 increased energy expenditure, physical activity, insulin sensitivity, and whole-body glucose turnover. Interestingly, E2 decreased the tight junction protein occludin, suggesting E2 affects gut epithelial integrity. Moreover, E2 increased
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.