ArticleMetabolites2021
Modeling the Influence of Chronic Sleep Restriction on Cortisol Circadian Rhythms, with Implications for Metabolic Disorders.
Article in Metabolites, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Sleep loss as a cardiometabolic risk factor: a narrative review of clinical and public health implications.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Review
- Sleep Duration and Mortality in Women: Effect of Aging and Menopause.Sleep medicine clinics · 2026Review
- Joint trajectories of sleep duration and depressive symptoms and risk of incident multimorbidity: a longitudinal analysis with machine learning prediction.BMC geriatrics · 2026Article
- The Role of Exercise in Cardiovascular Metabolism and Its Importance for Adolescent Metabolic Health.Advances in experimental medicine and biology · 2026Review
- Comorbidity patterns and immune-metabolic differences in patients with acute-episode of schizophrenia spectrum disorders.Schizophrenia (Heidelberg, Germany) · 2025Article
- Investigating the associations between weekend catch-up sleep and insulin resistance: NHANES cross-sectional study.BMC medicine · 2025Article
- Modified Cortisol Circadian Rhythm: The Hidden Toll of Night-Shift Work.International journal of molecular sciences · 2025Review
- Study on the Mechanisms of Ischemic Stroke Impacting Sleep Homeostasis and Circadian Rhythms in Rats.CNS neuroscience & therapeutics · 2025Article
- Understanding zebrafish sleep and wakefulness physiology as an experimental model for biomedical research.Fish physiology and biochemistry · 2024Review
- Demographic variables, anthropometric indices, sleep quality, Metabolic Equivalent Task (MET), and developing diabetes in the southwest of Iran.Frontiers in public health · 2023Article
- Role of Sleep Restriction in Daily Rhythms of Expression of Hypothalamic Core Clock Genes in Mice.Current issues in molecular biology · 2022Article
- The links between sleep duration, obesity and type 2 diabetes mellitus.The Journal of endocrinology · 2021Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Chronic sleep deficiency is prevalent in modern society and is associated with increased risk of metabolic and other diseases. While the mechanisms by which chronic sleep deficiency induces pathophysiological changes are yet to be elucidated, the hypothalamic-pituitary-adrenal (HPA) axis may be an important mediator of these effects. Cortisol, the primary hormone of the HPA axis, exhibits robust circadian rhythmicity and is moderately influenced by sleep and wake states and other physiology. Several studies have explored the effects of acute or chronic sleep deficiency (i.e., usually from self-selected chronic sleep restriction, CSR) on the HPA axis. Quantifying long-term changes in the circadian rhythm of cortisol under CSR in controlled conditions is inadequately studied due to practical limitations. We use a semi-mechanistic mathematical model of the HPA axis and the sleep/wake cycle to explore the influence of CSR on cortisol circadian rhythmicity. In qualitative agreement with experimental findings, model simulations predict that CSR results in physiologically relevant disruptions in the phase and amplitude of the cortisol rhythm. The mathematical model presented in this work provides a mechanistic framework to further explore how CSR might lead to HPA axis disruption and subsequent development of chronic metabolic complications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.