Evidence map›Paper›PMID 34436312›Full record

ArticleMembranes2021

Protein Crystallization in a Microfluidic Contactor with Nafion

M Polino, H S Rho, M P Pina, R Mallada, A L Carvalho, M J Romão, Isabel Coelhoso, J G E Gardeniers, J G Crespo, Carla A M Portugal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Membranes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

M PolinoLAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal.
H S RhoDepartment of Instructive Biomaterials Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, 6229 ER Maastricht, The Netherlands.ORCID 0000-0002-5345-3965
M P PinaInstituto de Nanociencia y Materiales de Aragón (INMA), Universidad de Zaragoza-CSIC, 50009 Zaragoza, Spain.ORCID 0000-0001-9897-6527
R MalladaInstituto de Nanociencia y Materiales de Aragón (INMA), Universidad de Zaragoza-CSIC, 50009 Zaragoza, Spain.ORCID 0000-0002-4758-9380
A L CarvalhoUCIBIO-Applied Molecular Biosciences Unit, Department of Chemistry, School of Science and Technology, NOVA University Lisbon, 2819-516 Caparica, Portugal.ORCID 0000-0002-3824-0240
M J RomãoUCIBIO-Applied Molecular Biosciences Unit, Department of Chemistry, School of Science and Technology, NOVA University Lisbon, 2819-516 Caparica, Portugal.
Isabel CoelhosoLAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal.ORCID 0000-0001-7032-3436
J G E GardeniersMesoscale Chemical Systems, TNW Faculty, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.ORCID 0000-0003-0581-2668
J G CrespoLAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal.
Carla A M PortugalLAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal.

Funding

Education, Audiovisual and Culture Executive Agency Erasmus Mundus Doctorate in Membrane Engineering" - EUDIME (FPA 2011-2014, http://www.eudime.unical.it)Fundação para a Ciência e a Tecnologia UIDB/50006/2020 and UIDP/50006/2020
6 · The paper itself

Abstract

Protein crystallization still remains mostly an empirical science, as the production of crystals with the required quality for X-ray analysis is dependent on the intensive screening of the best protein crystallization and crystal's derivatization conditions. Herein, this demanding step was addressed by the development of a high-throughput and low-budget microfluidic platform consisting of an ion exchange membrane (117 Nafion

Indexed as

membrane contactorsNafion® membraneprotein crystallizationprotein structuresolute diffusion

Identifiers

PMID34436312
PMCPMC8398885

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.