Evidence map›Paper›PMID 34436300›Full record

ReviewMarine drugs2021

Culturable Microorganisms Associated with Sea Cucumbers and Microbial Natural Products.

Lei Chen, Xiao-Yu Wang, Run-Ze Liu, Guang-Yu Wang

Abstract readReview
In one paragraph

Review in Marine drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Draft genome sequence ofMicrobiology resource announcements · 2026
    Article
  4. Microorganisms · 2025
    Article
  5. Article
  6. bioRxiv : the preprint server for biology · 2025
    Article
  7. Review
  8. Effect ofMolecules (Basel, Switzerland) · 2024
    Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lei ChenDepartment of Bioengineering, School of Marine Science and Technology, Harbin Institute of Technology at Weihai, Weihai 264209, China.ORCID 0000-0002-9973-4738
Xiao-Yu WangDepartment of Bioengineering, School of Marine Science and Technology, Harbin Institute of Technology at Weihai, Weihai 264209, China.
Run-Ze LiuDepartment of Bioengineering, School of Marine Science and Technology, Harbin Institute of Technology at Weihai, Weihai 264209, China.
Guang-Yu WangDepartment of Bioengineering, School of Marine Science and Technology, Harbin Institute of Technology at Weihai, Weihai 264209, China.

Funding

Discipline Construction Guide Foundation in Harbin Institute of Technology at Weihai WH20150204 and WH20160205Research Innovation Foundation in Harbin Institute of Technology at Weihai 2019KYCXJJYB15
6 · The paper itself

Abstract

Sea cucumbers are a class of marine invertebrates and a source of food and drug. Numerous microorganisms are associated with sea cucumbers. Seventy-eight genera of bacteria belonging to 47 families in four phyla, and 29 genera of fungi belonging to 24 families in the phylum Ascomycota have been cultured from sea cucumbers. Sea-cucumber-associated microorganisms produce diverse secondary metabolites with various biological activities, including cytotoxic, antimicrobial, enzyme-inhibiting, and antiangiogenic activities. In this review, we present the current list of the 145 natural products from microorganisms associated with sea cucumbers, which include primarily polyketides, as well as alkaloids and terpenoids. These results indicate the potential of the microorganisms associated with sea cucumbers as sources of bioactive natural products.

Indexed as

Biological ProductsAnimalsAquatic OrganismsFungiSea CucumbersBiological Productsalkaloidsbioactivitydiversitymicroorganismpolyketidessea cucumber

Identifiers

PMID34436300
PMCPMC8400260

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.