ReviewBehavioral sciences (Basel, Switzerland)2021
A Biopsychosocial Approach to Grief, Depression, and the Role of Emotional Regulation.
Review in Behavioral sciences (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Suicidal incidence and gender-based discrepancies in prolonged grief disorder: insights from a meta-analysis and systematic review.Frontiers in psychiatry · 2024Pooled it
- The Effectiveness of Online Thematic Expressive Writing on Prolonged Grief Disorder, Anxiety, Depression, and Positive Mental Health among Refugees in the Transition Stage of Asylum Seeking.Journal of immigrant and minority health · 2026Trial
- Multiple Pre-Treatment miRNAs Levels in Untreated Major Depressive Disorder Patients Predict Early Response to Antidepressants and Interact with Key Pathways.International journal of molecular sciences · 2022Trial
- Investigating the Relationship between Childhood Trauma and Attachment Styles with Prolonged Grief Symptoms.Iranian journal of psychiatry · 2026Article
- Associations between positive and negative social experiences and epigenetic aging.Scientific reports · 2025Article
- Associations of depressive symptoms, social engagement and support, and lifestyle behaviors among non-Hispanic black and Hispanic men with chronic conditions in the United States.Frontiers in public health · 2025Article
- Understanding immune system dysfunction and its context in mood disorders: psychoneuroimmunoendocrinology and clinical interventions.Military Medical Research · 2024Review
- The nature of grief: implications for the neurobiology of emotion.Neuroscience of consciousness · 2024Article
- Nurses' experiences of the family's role in end-of-life care.Health SA = SA Gesondheid · 2024Article
- Antidepressant Effect of Intermittent Long-Term Systemic Administration of Irisin in Mice.International journal of molecular sciences · 2022Article
- The grief experience during the COVID-19 pandemic across different cultures.Annals of general psychiatry · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
According to the field of affective neuroscience, grief has been identified as one of the seven primary emotions necessary for human survival. However, maladaptive grief could cause significant impairment in an individual's life, leading to psychopathologies such as major depressive disorder. Research on grief has shifted to a biopsychosocial approach, leaving behind outdated models-such as the Kübler-Ross theory-that have shown poor consistency. The field of psychoneuroimmunology has identified adverse life events such as social loss as being associated with major depressive disorder, and inflammatory processes in chronic health conditions. Likewise, scientists in the field of affective neuroscience have theorized that prolonged and sustained activation of the grief neurological pathway can cause a cascade of neurotransmitters that inhibits the reward-seeking system, causing symptoms of depression. The objective of this review is to highlight findings on the grief process using a biopsychosocial approach to explore grief's impact on psychopathophysiology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.