Evidence map›Paper›PMID 34436051›Full record

ArticleBiosensors2021

On-Chip Glucose Detection Based on Glucose Oxidase Immobilized on a Platinum-Modified, Gold Microband Electrode.

Julia Madden, Colm Barrett, Fathima R Laffir, Michael Thompson, Paul Galvin, Alan O' Riordan

Open access · goldAbstract read
In one paragraph

Article in Biosensors, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
  3. Exosome-mediated lnc-ABCA12-3 promotes proliferation and glycolysis but inhibits apoptosis by regulating the toll-like receptor 4/nuclear factor kappa-B signaling pathway in esophageal squamous cell carcinoma.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2023
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Julia MaddenTyndall National Institute, University College Cork, T12 R5CP Cork, Ireland.
Colm BarrettTyndall National Institute, University College Cork, T12 R5CP Cork, Ireland.ORCID 0000-0002-8334-1593
Fathima R LaffirBernal Institute, University of Limerick, V94 T9PX Limerick, Ireland.
Michael ThompsonTyndall National Institute, University College Cork, T12 R5CP Cork, Ireland.ORCID 0000-0002-1445-9918
Paul GalvinTyndall National Institute, University College Cork, T12 R5CP Cork, Ireland.
Alan O' RiordanTyndall National Institute, University College Cork, T12 R5CP Cork, Ireland.ORCID 0000-0002-7554-1536
University College Cork · IEUniversity of Limerick · IEUniversity of Toronto · CA

Funding

Science Foundation Ireland 12/RC/2289Science Foundation Ireland 12/RC/2289-P2Science Foundation Ireland 16/RC/3835
6 · The paper itself

Abstract

We report the microfabrication and characterization of gold microband electrodes on silicon using standard microfabrication methods, i.e., lithography and etching techniques. A two-step electrodeposition process was carried out using the on-chip platinum reference and gold counter electrodes, thus incorporating glucose oxidase onto a platinum-modified, gold microband electrode with an o-phenylenediamine and ß-cyclodextrin mixture. The as-fabricated electrodes were studied using optical microscopy, scanning electron microscopy, and atomic force microscopy. The two-step electrodeposition process was conducted in low sample volumes (50 µL) of both solutions required for biosensor construction. Cyclic voltammetry and electrochemical impedance spectroscopy were utilised for electrochemical characterization at each stage of the deposition process. The enzymatic-based microband biosensor demonstrated a linear response to glucose from 2.5-15 mM, using both linear sweep voltammetry and chronoamperometric measurements in buffer-based solutions. The biosensor performance was examined in 30 µL volumes of fetal bovine serum. Whilst a reduction in the sensor sensitivity was evident within 100% serum samples (compared to buffer media), the sensor demonstrated linear glucose detection with increasing glucose concentrations (5-17 mM).

Indexed as

Biosensing TechniquesGlucose OxidaseElectrodesEnzymes, ImmobilizedGlucoseGoldPlatinumEnzymes, ImmobilizedGlucoseGlucose OxidaseGoldPlatinumelectrochemicalenzymaticglucose detectionmicrobandmicrofabricationsilicon

Identifiers

PMID34436051
PMCPMC8392376
OpenAlexW3138136337

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.