ReviewCurrent oncology (Toronto, Ont.)2021
Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.
Review in Current oncology (Toronto, Ont.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
83 citing papers in PubMed, 120 citations in OpenAlex.
- Dramatic response to trastuzumab-deruxtecan in metastatic HER2-overexpressing vulvar extramammary Paget's disease: A case report.Gynecologic oncology reports · 2026Article
- Concurrent chemoradiotherapy for metastatic vulvar extramammary Paget's disease involving supraclavicular nodes: a case report.Radiation oncology journal · 2026Article
- Treatment Strategies for Extramammary Paget Disease: A Narrative Review of Current Status and Future Directions.Cancers · 2026Review
- Vulvar Extramammary Paget Disease: Diagnostic Challenge and Surgical Management in a Case Report.Healthcare (Basel, Switzerland) · 2026Article
- Primary extramammary Paget disease of the male genitalia with very late (11-year) recurrence.JAAD case reports · 2026Article
- Factors Related to Recurrence Rates of Extramammary Paget Disease: A Case Series and Literature Review.Archives of plastic surgery · 2026Article
- Clinicopathologic, molecular, and treatment features of metastatic and distantly recurrent extramammary Paget disease: Mayo clinic experience.The oncologist · 2026Article
- Treatment of extramammary Paget's disease with sirolimus: A case series.JAAD case reports · 2026Article
- Immunohistochemical evaluation of gastric-type markers in primary extramammary Paget disease: Differential MUC5AC expression betweenExperimental and therapeutic medicine · 2026Article
- Double Lotus Petal Flaps for Large Perianal Defect Reconstruction After Multistage Extramammary Paget Resection.Plastic and reconstructive surgery. Global open · 2026Article
- Imaging features of an extramammary Paget's disease of the penis: A case report and literature review.Radiology case reports · 2026Article
- Management of Extramammary Paget Disease of the Male Genital Region: A Narrative Review and Two Case Reports.Journal of clinical medicine · 2026Review
- Case Report: Complete remission after radiotherapy in two cases of locally advanced extramammary Paget's disease of the perineum.Frontiers in oncology · 2026Article
- Metastatic extramammary Paget's disease successfully treated by trastuzumab deruxtecan: a rare case report.Frontiers in medicine · 2026Article
- Photodynamic technology for delineating surgical margins in recurrent extramammary Paget's disease: a case report.Frontiers in medicine · 2026Article
- Comparison of clinical and dermoscopic features between extramammary Paget's disease and chronic eczema.Frontiers in medicine · 2026Article
- Therapeutic Algorithm for Extramammary Paget Disease: Experience in a Dermatology Referral Center in Western Mexico.Cureus · 2026Article
- HER2-directed therapy in metastatic vulvar empd-a report of two cases and narrative review.AME case reports · 2026Article
- Case Report: HER2-positive vulvar Paget disease achieving long-term control with trastuzumab-based systemic therapy plus radiotherapy.Frontiers in medicine · 2026Article
- Case Report: Digital CTA-assisted anterolateral thigh perforator pedicled flap for repairing postoperative defects in Vulvar Paget's disease.Frontiers in medicine · 2026Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extramammary Paget's disease (EMPD) is a rare neoplasm that usually develops in apocrine gland-bearing areas, such as the vulva, scrotum, and penis. EMPD may present with a focal, multifocal, or an ectopic lesion. Clinically, EMPD lesions often exhibit infiltrative erythema, which is sometimes similar to other skin disorders such as eczema. While primary EMPD arises as intraepithelial neoplasm of the epidermis, EMPD-like lesions may occur from epidermotropic spread of malignant cells or direct extension from an underlying internal neoplasm, known as secondary EMPD. Because treatment strategies differ for primary EMPD and secondary EMPD, accurate diagnosis based on detailed histopathological evaluation is required. In the early stages, EMPD usually shows indolent growth, and most cases are diagnosed as carcinoma in situ. However, invasive lesions may result in metastases, and deep invasion is associated with high incidence of metastases. Conventional chemotherapies have been used for EMPD treatment in patients with distant metastases, but the efficacy is not satisfactory, and the prognosis for such patients remains poor. Recent studies have provided various insights into the molecular pathogenesis of the development and advancement of EMPD, which may lead to novel treatment approaches for metastatic EMPD. This review addresses the diagnosis, pathogenesis, and treatment of EMPD with focus on recent progress in understanding this disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.