ArticleAnnals of the Royal College of Surgeons of England2021
Toxic adenoma: to biopsy or not to biopsy?
Article in Annals of the Royal College of Surgeons of England, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- Papillary thyroid carcinoma in a hyperfunctioning autonomous nodule : A diagnostic paradox challenging clinical guidelines.Caspian journal of internal medicine · 2026Article
- Reappraising the role of thyroid scintigraphy in the era of TIRADS: A clinically-oriented viewpoint.Endocrine · 2024Review
- Risk of TIRADS-based inappropriate FNAC in autonomous thyroid nodules is clinically negligible.European thyroid journal · 2024Article
- Article
- Management of Thyroid Nodules.Sisli Etfal Hastanesi tip bulteni · 2023Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Toxic adenoma nodules rarely harbour cancer. Fine-needle aspiration (FNA) is often not done because of the rarity of these lesions being cancer, the difficulty in interpreting cytology in hyperthyroid patients and the rare precipitation of thyrotoxicosis. We present two young, Caucasian female patients aged 29 and 13 years who were each diagnosed with a toxic nodule categorised as benign and indeterminate respectively. They underwent hemithyroidectomy after being rendered euthyroid, however their histology unexpectedly revealed differentiated follicular cancer. Despite thyroid cancer being rare in patients with toxic adenomas, it should be considered when planning treatment, especially if there are risk factors for cancer, or suspicious features on ultrasound examination. A review of the literature shows that compared with adenomas in euthyroid patients, patients in this group are generally younger and predominately female. If an FNA is considered, it should be performed after the patient is rendered euthyroid.
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