ReviewJournal of women's health (2002)2021
Bone Mineral Density Changes Associated With Pregnancy, Lactation, and Medical Treatments in Premenopausal Women and Effects Later in Life.
Review in Journal of women's health (2002), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Comparative Effectiveness of Therapeutic Interventions in Pregnancy and Lactation-Associated Osteoporosis: A Systematic Review and Meta-analysis.The Journal of clinical endocrinology and metabolism · 2024Pooled it
- A Randomized Open-Label Study of Relugolix Alone or Relugolix Combination Therapy in Premenopausal Women.Clinical pharmacokinetics · 2023Trial
- Changes in human skull bone marrow during pregnancy and postpartum: an exploratory case report.BMC pregnancy and childbirth · 2026Article
- Safety of 48 months of elagolix with add-back therapy for endometriosis-associated pain.AJOG global reports · 2026Article
- Heterogeneity in Lumbar Segmental Bone Mineral Density and Age-Related Evolution of Whole-Body Bone Mineral Density: Comprehensive Implications for Osteoporosis Risk Assessment.Orthopaedic surgery · 2026Article
- The Role of Diet in Women of Childbearing Age: Current Evidence Supporting Nutritional Recommendations.Nutrients · 2025Review
- Bone mineral density with elagolix plus add-back therapy in women with heavy menstrual bleeding and uterine fibroids: open-label and post-treatment results of a 60-month phase 3 trial.AJOG global reports · 2025Article
- Traumatic ulna fracture with plastic deformation of the radius in a skeletally mature pregnant female: a case report.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Article
- The U-curve associations of birth interval with prevalence of osteoarthritis in postmenopausal women.Aging clinical and experimental research · 2025Article
- Bone Health for Gynaecologists.Medicina (Kaunas, Lithuania) · 2025Review
- Recurrent Aggressive Angiomyxoma That Responded to the Gonadotropin-Releasing Hormone (GnRH) Antagonist Relugolix.Cureus · 2025Article
- Two-year follow-up study (PRIMROSE 3) to assess bone mineral density in subjects with uterine fibroids completing the PRIMROSE 1 and PRIMROSE 2 linzagolix trials.Human reproduction open · 2025Article
- Wild bonobos experience unusually low bone resorption during early lactation relative to humans and other mammals.Evolutionary human sciences · 2025Article
- Osteoporosis Is Associated with an Increased Risk of Colorectal Neoplasms Regardless of Sex: Nationwide Population-Based Cohort Study.Diagnostics (Basel, Switzerland) · 2024Article
- Safety evaluation of medroxyprogesterone acetate: a pharmacovigilance analysis using FDA adverse event reporting system data.Frontiers in pharmacology · 2024Article
- Bridging the Gap: Pregnancy-And Lactation-Associated Osteoporosis.Diagnostics (Basel, Switzerland) · 2023Review
- The effect of daily oral PrEP use during pregnancy on bone mineral density among adolescent girls and young women in Uganda.Frontiers in reproductive health · 2023Article
- Crosstalk within a brain-breast-bone axis regulates mineral and skeletal metabolism during lactation.Frontiers in physiology · 2023Review
- Sex Differences in Biological Systems and the Conundrum of Menopause: Potential Commonalities in Post-Menopausal Disease Mechanisms.International journal of molecular sciences · 2022Review
- Osteoporosis, Rather Than Sarcopenia, Is the Predominant Musculoskeletal Disease in a Rural South African Community Where Human Immunodeficiency Virus Prevalence Is High: A Cross-Sectional Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 7 institutions in 1 country.
Funding
Abstract
Bone mineral density (BMD) changes during the life span, increasing rapidly during adolescence, plateauing in the third decade of life, and subsequently entering a phase of age-related decline. In women, menopause leads to accelerated bone loss and an increase in fracture risk. Between peak bone mass attainment and menopause, BMD is generally stable and the risk of fracture is typically low. This time period is marked by life events such as pregnancy and lactation, which transiently decrease BMD, yet their long-term effects on fracture risk are less certain. BMD may also be altered by exposure to medications that affect bone metabolism (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.