ArticleJournal of neurotrauma2021
Alterations in the Topology of Functional Connectomes Are Associated with Post-Traumatic Stress Disorder and Blast-Related Mild Traumatic Brain Injury in Combat Veterans.
Article in Journal of neurotrauma, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Neuroimaging Correlates of Post-Traumatic Stress Disorder in Traumatic Brain Injury: A Systematic Review of the Literature.Journal of neurotrauma · 2023Pooled it
- Post-traumatic stress disorder: pathogenesis, epidemiological characteristics, animal models, and potential therapeutic strategies.Military Medical Research · 2026Review
- Mild traumatic brain injury increases vulnerability to post-traumatic stress disorder in rats and the possible role of hippocampal DNA methylation.Frontiers in behavioral neuroscience · 2025Article
- Differences in Brain Volume in Military Service Members and Veterans After Blast-Related Mild TBI: A LIMBIC-CENC Study.JAMA network open · 2024Article
- Convergent and Discriminant Validity of the Blast Exposure Threshold Survey in United States Military Service Members and Veterans.Journal of neurotrauma · 2024Article
- Repetitive subconcussion results in disrupted neural activity independent of concussion history.Brain communications · 2024Article
- Considerations for the assessment of blast exposure in service members and veterans.Frontiers in neurology · 2024Article
- Blast-related mild TBI: LIMBIC-CENC focused review with implications commentary.NeuroRehabilitation · 2024Review
- Polygenic risk for mental disorders as predictors of posttraumatic stress disorder after mild traumatic brain injury.Translational psychiatry · 2023Article
- Use of magnetic source imaging to assess recovery after severe traumatic brain injury-an MEG pilot study.Frontiers in neurology · 2023Article
- Perspectives on Development of Measures to Estimate Career Blast Exposure History in Service Members and Veterans.Frontiers in neurology · 2022Article
- Traumatic Brain Injury and Accelerated Epigenetic Aging Among Post-9/11 Veterans.The Journal of head trauma rehabilitationArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Post-traumatic stress disorder (PTSD) is a common condition in post-deployment service members (SM). SMs of the conflicts in Iraq and Afghanistan also frequently experience traumatic brain injury (TBI) and exposure to blasts during deployments. This study evaluated the effect of these conditions and experiences on functional brain connectomes in post-deployment, combat-exposed veterans. Functional brain connectomes were created using 5-min resting-state magnetoencephalography data. Well-established clinical interviews determined current PTSD diagnosis, as well as deployment-acquired mild TBI and history of exposure to blast. Linear regression examined the effect of these conditions on functional brain connectomes beyond covariates. There were significant interactions between blast-related mild TBI and PTSD after correction for multiple comparisons including number of nodes (non-standardized parameter estimate [PE] = -12.47), average degree (PE = 0.05), and connection strength (PE = 0.05). A main effect of blast-related mild TBI was observed on the threshold level. These results demonstrate a distinct functional connectome presentation associated with the presence of both blast-related mild TBI and PTSD. These findings suggest the possibility that blast-related mild TBI alterations in functional brain connectomes affect the presentation or progression of recovery from PTSD. The current results offer mixed support for hyper-connectivity in the chronic phase of deployment TBI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.