Evidence map›Paper›PMID 34435646›Full record

ArticleMolecular medicine reports2021

Role of the CXCR3‑mediated TLRs/MyD88 signaling pathway in promoting the development of hepatitis B into cirrhosis and liver cancer.

Gang Yuan, Bin Chen, Yina Meng, Jialin Lu, Xiaojun Shi, Airong Hu, Yaoren Hu, Donghui Wang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Gang YuanDepartment of Acute Infection, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang 315010, P.R. China.
Bin ChenHepatology Center, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang 315010, P.R. China.
Yina MengInstitute of Hepatology, Ningbo University School of Medicine, Ningbo, Zhejiang 315211, P.R. China.
Jialin LuInstitute of Hepatology, Ningbo University School of Medicine, Ningbo, Zhejiang 315211, P.R. China.
Xiaojun ShiDepartment of Hepato‑Oncology, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang 315010, P.R. China.
Airong HuInstitute of Hepatology, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang 315010, P.R. China.
Yaoren HuInstitute of Hepatology, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang 315010, P.R. China.
Donghui WangDepartment of Acute Infection, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang 315010, P.R. China.
University of Chinese Academy of Sciences · CNNingbo University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic hepatitis B can lead to liver cirrhosis and primary hepatocellular carcinoma. The present study aimed to investigate whether C‑X‑C motif chemokine receptor 3 (CXCR3) regulates the genes in Toll‑like receptors (TLRs)/myeloid differentiation primary response protein 88 (MyD88) signaling pathway in the development of hepatitis B into cirrhosis and liver cancer

Indexed as

Signal TransductionAgedApoptosisCell LineCell MovementCell SurvivalCollagenCollagen Type I, alpha 1 ChainFemaleFibrosisHepatitis B, ChronicHepatitis B virusHumansInterleukin-1betaInterleukin-6Liver CirrhosisCOL1A1 protein, humanCollagenCollagen Type I, alpha 1 ChainCXCR3 protein, humanIL1B protein, humanIL6 protein, humanInterleukin-1betaInterleukin-6MYD88 protein, humanMyeloid Differentiation Factor 88Receptors, CXCR3Toll-Like ReceptorsC‑X‑C motif chemokine receptor 3hepatitis B virusliver cirrhosismyeloid differentiation primary response protein 88Toll‑like receptors

Identifiers

PMID34435646
PMCPMC8404096
OpenAlexW3194282901

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.