Evidence map›Paper›PMID 34435466›Full record

ArticlePhysiological reports2021

Differential inflammatory responses of the native left and right ventricle associated with donor heart preservation.

Ienglam Lei, Wei Huang, Peter A Ward, Jordan S Pober, George Tellides, Gorav Ailawadi, Francis D Pagani, Andrew P Landstrom, Zhong Wang, Richard M Mortensen and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Ienglam LeiDepartment of Cardiac Surgery, University of Michigan Frankel Cardiovascular Center, Ann Arbor, Michigan, USA.
Wei HuangDepartment of Cardiac Surgery, University of Michigan Frankel Cardiovascular Center, Ann Arbor, Michigan, USA.
Peter A WardDepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Jordan S PoberDepartment of Immunobiology, Yale University, New Haven, Connecticut, USA.
George TellidesDepartment of Surgery, Yale University, New Haven, Connecticut, USA.
Gorav AilawadiDepartment of Cardiac Surgery, University of Michigan Frankel Cardiovascular Center, Ann Arbor, Michigan, USA.
Francis D PaganiDepartment of Cardiac Surgery, University of Michigan Frankel Cardiovascular Center, Ann Arbor, Michigan, USA.
Andrew P LandstromDepartment of Pediatrics, Duke University, Durham, North Carolina, USA.
Zhong WangDepartment of Cardiac Surgery, University of Michigan Frankel Cardiovascular Center, Ann Arbor, Michigan, USA.
Richard M MortensenDepartment of Internal Medicine, University of Michigan Frankel Cardiovascular Center, Ann Arbor, Michigan, USA.
Marilia CascalhoDepartment of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Jeffrey PlattDepartment of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Yuqing Eugene ChenDepartment of Cardiac Surgery, University of Michigan Frankel Cardiovascular Center, Ann Arbor, Michigan, USA.
Hugo Yu Kor LamHypahub Inc, San Jose, California, USA.
Paul C TangDepartment of Cardiac Surgery, University of Michigan Frankel Cardiovascular Center, Ann Arbor, Michigan, USA.ORCID 0000-0003-4211-8587
University of Michigan · USYale University · USDuke University · USMichigan Medicine · US

Funding

Donor-specific B cells in Transplantation.R01AI151588 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CASCALHO, MARILIA ISABEL, PLATT, JEFFREY L · 2020 to 2025
$2.7M
Ex Vivo Nanoparticle Drug Delivery Targeted to Human Renal Allograft EndotheliumU01AI132895 · NIAID · YALE UNIVERSITY · PI POBER, JORDAN S, SALTZMAN, W. MARK · 2017 to 2021
$2.2M
Immunodeficient Pigs for Stem Cell­-Based Regenerative MedicineR01OD023138 · OD · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI PIEDRAHITA, JORGE A · 2017 to 2020
$1.8M
Nanofibrous self-gelling microspheres for heart regenerationR01HL139735 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MA, PETER X, WANG, ZHONG · 2019 to 2022
$1.6M
NHLBI NIH HHS R01 HL139735NIAID NIH HHS U01 AI132895NIH HHS R01 OD023138
6 · The paper itself

Abstract

backgroundDysfunction and inflammation of hearts subjected to cold ischemic preservation may differ between left and right ventricles, suggesting distinct strategies for amelioration. METHODS AND

resultsExplanted murine hearts subjected to cold ischemia for 0, 4, or 8 h in preservation solution were assessed for function during 60 min of warm perfusion and then analyzed for cell death and inflammation by immunohistochemistry and western blotting and total RNA sequencing. Increased cold ischemic times led to greater left ventricle (LV) dysfunction compared to right ventricle (RV). The LV experienced greater cell death assessed by TUNEL

conclusionsMouse hearts subjected to cold ischemia showed time-dependent contractile dysfunction and increased cell death, inflammatory cytokine expression and inflammasome expression that are greater in the LV than RV. However, IL-6 protein elevations and altered transcriptional profiles were similar in both ventricles. Similar changes are observed in human hearts.

Indexed as

AnimalsCold TemperatureFemaleHeart TransplantationHeart VentriclesHumansInflammation MediatorsMaleMiceMice, Inbred C57BLMiddle AgedMyocardial IschemiaOrgan Preservation SolutionsTissue DonorsVentricular Dysfunction, LeftVentricular Dysfunction, RightInflammation MediatorsOrgan Preservation Solutionscontractile functioninflammationischemiamyocardial biologytransplantation

Identifiers

PMID34435466
PMCPMC8387788
OpenAlexW3194278143

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.