Evidence map›Paper›PMID 34435462›Full record

ArticlePhysiological reports2021

Open or closed: Changes in ductus arteriosus flow patterns at birth using 4D flow MRI in newborn piglets.

Eric M Schrauben, Jack R T Darby, Mary J Berry, Brahmdeep S Saini, Megan Quinn, Stacey L Holman, Emma L Bradshaw, Mitchell C Lock, Sunthara R Perumal, Steven K S Cho and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Advanced imaging of fetal cardiac function.Frontiers in cardiovascular medicine · 2023
    Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Eric M SchraubenTranslational Medicine, Hospital for Sick Children, Toronto, ON, Canada.ORCID 0000-0002-7922-3615
Jack R T DarbyEarly Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
Mary J BerryCentre for Translational Physiology & Department of Pediatrics and Child Health, University of Otago, Wellington, New Zealand.
Brahmdeep S SainiHeart Centre, Hospital for Sick Children, Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Megan QuinnEarly Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
Stacey L HolmanEarly Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
Emma L BradshawEarly Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
Mitchell C LockEarly Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.ORCID 0000-0002-3594-1455
Sunthara R PerumalPreclinical Imaging and Research Laboratories, South Australian Health & Medical Research Institute, Adelaide, SA, Australia.
Steven K S ChoEarly Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
Tanroop AujlaEarly Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
Mike SeedDivision of Cardiology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Christopher K MacgowanTranslational Medicine, Hospital for Sick Children, Toronto, ON, Canada.
Janna L MorrisonEarly Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.ORCID 0000-0002-8602-8519
University of South Australia · AUUniversity of Toronto · CAHospital for Sick Children · CASouth Australian Health and Medical Research Institute · AUUniversity of Otago · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ductus arteriosus (DA) functionally closes during the transition from fetal to postnatal life because of lung aeration and corresponding cardiovascular changes. The thorough and explicit measurement and visualization of the right and left heart output during this transition has not been previously accomplished. We combined 4D flow MRI (dynamic volumetric blood flow measurements) and T2 relaxometry (oxygen delivery quantification) in surgically instrumented newborn piglets to assess the DA. This was performed in Large White-Landrace-Duroc piglets (n = 34) spanning four age groups: term-9 days, term-3, term+1, and term+5. Subject's DA status was classified using 4D flow: closed DA, forward DA flow, reversed DA flow, and bidirectional DA flow. Over all states, vessel diameters and flows normalized to body weight increased with age (for example in the ascending aorta flow-term-9: 126.6 ± 45.4; term+5: 260.2 ± 80.0 ml/min per kg; p = 0.0005; ascending aorta diameter-term-9: 5.2 ± 0.8; term+5: 7.7 ± 0.4 mm; p = 0.0004). In subjects with reversed DA blood flow there was lower common carotid artery blood flow (forward: 37.5 ± 9.0; reversed: 20.0 ± 7.4 ml/min per kg; p = 0.032). Linear regression revealed that as net DA flow decreases, common carotid artery flow decreases (R

Indexed as

AnimalsAnimals, NewbornBlood Flow VelocityDuctus ArteriosusFemaleMagnetic Resonance AngiographyMagnetic Resonance ImagingMaleRegional Blood FlowSwine4D flow MRIductus arteriosusnewborn

Identifiers

PMID34435462
PMCPMC8387787
OpenAlexW3193743009

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.