Evidence map›Paper›PMID 34435425›Full record

ArticleChemphyschem : a European journal of chemical physics and physical chemistry2021

How Divalent Cations Interact with the Internal Channel Site of Guanine Quadruplexes.

Francesco Zaccaria, Stephanie C C van der Lubbe, Celine Nieuwland, Trevor A Hamlin, Célia Fonseca Guerra

Open access · hybridAbstract read
In one paragraph

Article in Chemphyschem : a European journal of chemical physics and physical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

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  7. How Divalent Cations Interact with the Internal Channel Site of Guanine Quadruplexes.Chemphyschem : a European journal of chemical physics and physical chemistry · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Francesco ZaccariaDepartment of Theoretical Chemistry and, Amsterdam Center for Multiscale Modelling, AIMMS, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands.ORCID 0000-0003-3636-9830
Stephanie C C van der LubbeDepartment of Theoretical Chemistry and, Amsterdam Center for Multiscale Modelling, AIMMS, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands.ORCID 0000-0002-9723-7017
Celine NieuwlandDepartment of Theoretical Chemistry and, Amsterdam Center for Multiscale Modelling, AIMMS, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands.ORCID 0000-0002-5855-4386
Trevor A HamlinDepartment of Theoretical Chemistry and, Amsterdam Center for Multiscale Modelling, AIMMS, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands.ORCID 0000-0002-5128-1004
Célia Fonseca GuerraDepartment of Theoretical Chemistry and, Amsterdam Center for Multiscale Modelling, AIMMS, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands.ORCID 0000-0002-2973-5321
Scientific Computing & Modelling (Netherlands) · NLLeiden University · NL

Funding

Netherlands Organization for Scientific Research
6 · The paper itself

Abstract

The formation of guanine quadruplexes (GQ) in DNA is crucial in telomere homeostasis and regulation of gene expression. Pollution metals can interfere with these DNA superstructures upon coordination. In this work, we study the affinity of the internal GQ channel site towards alkaline earth metal (Mg

Indexed as

G-QuadruplexesCations, DivalentComputer SimulationDensity Functional TheoryEnvironmental PollutantsMetalsModels, MolecularNucleic Acid ConformationCations, DivalentEnvironmental PollutantsMetalsdensity functional calculationsdivalent cationsDNAenergy decomposition analysisguanine quadruplexes

Identifiers

PMID34435425
PMCPMC9293024
OpenAlexW4226289865

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.