Evidence map›Paper›PMID 34435355›Full record

ArticleBritish journal of haematology2022

Response to mitogen-activated protein kinase inhibition of neurodegeneration in Langerhans cell histiocytosis monitored by cerebrospinal fluid neurofilament light as a biomarker: a pilot study.

Jan-Inge Henter, Egle Kvedaraite, Daniel Martín Muñoz, Monica Cheng Munthe-Kaas, Bernward Zeller, Tove A Nystad, Caroline Björklund, Isabella Donnér, Magda Lourda, Henrik Zetterberg and 4 more

Open access · hybridAbstract readCase ReportsLetter
In one paragraph

Article in British journal of haematology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
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  4. Observational
  5. Article
  6. Review
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  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Langerhans cell histiocytosis: promises and caveats of targeted therapies in high-risk and CNS disease.Hematology. American Society of Hematology. Education Program · 2023
    Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 3 countries.

Jan-Inge HenterChildhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-0629-2126
Egle KvedaraiteChildhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-5308-092X
Daniel Martín MuñozDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Monica Cheng Munthe-KaasDepartment of Pediatric Hematology and Oncology, Oslo University Hospital, Oslo, Norway.
Bernward ZellerDepartment of Pediatric Hematology and Oncology, Oslo University Hospital, Oslo, Norway.ORCID 0000-0001-9008-4495
Tove A NystadDepartment of Pediatrics, Division of Child and Adolescent Health, University Hospital of North-Norway, Tromsø, Norway.
Caroline BjörklundDepartment of Pediatric Hematology and Oncology, Umeå University Hospital, Umeå, Sweden.
Isabella DonnérHallands Hospital, Halmstad, Sweden.
Magda LourdaChildhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-3155-1123
Henrik ZetterbergClinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Kaj BlennowClinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Nikolas HeroldChildhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Désirée GavhedChildhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Tatiana von Bahr GreenwoodChildhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-6322-8035
Karolinska University Hospital · SEOslo University Hospital · NOSahlgrenska University Hospital · SEHallands sjukhus Halmstad · SEKarolinska Institutet · SEUmeå University · SEUniversity Hospital of North Norway · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

BiomarkersChild, PreschoolDisease SusceptibilityFemaleHistiocytosis, Langerhans-CellHumansInfantMaleMitogen-Activated Protein KinasesMutationNeurofilament ProteinsPrognosisProtein Kinase InhibitorsTreatment OutcomeBiomarkersMitogen-Activated Protein Kinasesneurofilament protein LNeurofilament ProteinsProtein Kinase Inhibitorscentral nervous systemLangerhans cell histiocytosismitogen-activated protein kinase inhibitionneurodegenerationneurofilament light chain protein

Identifiers

PMID34435355
PMCPMC9292002
OpenAlexW3195631104

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.