Evidence map›Paper›PMID 34435310›Full record

ReviewClinical pharmacokinetics2021

Review of Transporter Substrate, Inhibitor, and Inducer Characteristics of Cladribine.

Robert Hermann, Peter Krajcsi, Markus Fluck, Annick Seithel-Keuth, Afrim Bytyqi, Andrew Galazka, Alain Munafo

Open access · hybridAbstract readReview
In one paragraph

Review in Clinical pharmacokinetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Current Chemical, Biological, and Physiological Views in the Development of Successful Brain-Targeted Pharmaceutics.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Robert HermannClinical Research Appliance (cr.appliance), Heinrich-Vingerhut-Weg 3, 63571, Gelnhausen, Germany. robert.hermann@cr-appliance.com.ORCID 0000-0002-1326-5943
Peter KrajcsiHabilitas Kft, Budapest, Hungary.
Markus FluckMerck Healthcare KGaA, Darmstadt, Germany.
Annick Seithel-KeuthMerck Healthcare KGaA, Darmstadt, Germany.
Afrim BytyqiMerck Healthcare KGaA, Darmstadt, Germany.
Andrew GalazkaMerck Healthcare KGaA, Darmstadt, Germany.
Alain MunafoInstitute of Pharmacometrics, an Affiliate of Merck KGaA, Lausanne, Switzerland.
Merck (Germany) · DEMerck Serono (Switzerland) · CHMine Safety Appliances (United States) · US

Funding

merck healthcare kgaa CrossRef Funder ID: 10.13039/100009945
6 · The paper itself

Abstract

Cladribine is a nucleoside analog that is phosphorylated in its target cells (B- and T-lymphocytes) to its active adenosine triphosphate form (2-chlorodeoxyadenosine triphosphate). Cladribine tablets 10 mg (Mavenclad

Indexed as

CladribineNeoplasm ProteinsATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily G, Member 2HumansMembrane Transport ProteinsATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily G, Member 2CladribineMembrane Transport ProteinsNeoplasm Proteins

Identifiers

PMID34435310
PMCPMC8613159
OpenAlexW3195291216

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.