Evidence map›Paper›PMID 34435281›Full record

ArticleCognitive, affective & behavioral neuroscience2022

The Neural Circuitry of Reward During Sustained Threat.

Anne E Penner, Emma White, Joel Stoddard, Joshua L Gowin

Abstract read
In one paragraph

Article in Cognitive, affective & behavioral neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Anne E PennerDepartment of Psychiatry, University of Colorado, Anschutz Medical Campus, Aurora, CO, 80045, USA. Anne.penner@childrenscolorado.org.
Emma WhiteDepartment of Radiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Joel StoddardDepartment of Psychiatry, University of Colorado, Anschutz Medical Campus, Aurora, CO, 80045, USA.
Joshua L GowinDepartment of Radiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Funding

Neural Correlates of Emotion Regulation in Youth at Risk for AlcoholismR00AA024778 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI GOWIN, JOSHUA LEIGH · 2018 to 2020
$747k
NIAAA NIH HHS R00 AA024778
6 · The paper itself

Abstract

Reward processing is important for understanding behavior in psychopathology. Opportunities to earn money activate the ventral striatum, as shown by the monetary incentive delay (MID) task. Anxiety conditions have been modeled by presenting shocks and startling sounds. To further investigate the co-occurrence of an anxiety condition and a rewarding stimulus, we modified the MID to include a sustained threat of scream. This study investigated neural patterns of the MID task with an uncertain threat of a startling scream. Forty-three young adults completed a functional MRI scan. The task included two conditions (scream and safe) and three cues (gain $5, gain $0, lose $5). Analyses included a whole brain, group analysis using a linear mixed-effects model and a paired t-test. The whole brain analysis revealed a main effect of cue, with increased ventral striatal activation (F

Indexed as

RewardVentral StriatumBrain MappingCuesHumansMagnetic Resonance ImagingMotivationYoung AdultNeuorimagingPutamenReward processingThreat taskVentral striatum

Identifiers

PMID34435281
PMCPMC12885127

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.