Evidence map›Paper›PMID 34435220›Full record

ArticleAesthetic plastic surgery2023

Palpable Nodules After Autologous Fat Grafting in Breast Cancer Patients: Incidence and Impact on Follow-up.

Pauline Dile, Karine Hannebicque, Céline Renaudeau, Émilie Bogart, Luc Ceugnart, Claudia Regis, Loïc Boulanger, Marie-Pierre Chauvet

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Article in Aesthetic plastic surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Pauline DileDepartment of Obstetrics, Jeanne de Flandre University Hospital, Avenue Eugène Avinée, 59000, Lille, France. dile.pauline@hotmail.fr.
Karine HannebicqueDepartment of Surgery, Centre Oscar Lambret, Lille, France.
Céline RenaudeauDepartment of Surgery, Institut de cancérologie de l'Ouest, Saint Herblain, France.
Émilie BogartBiostatistics Unit, Centre Oscar Lambret, Lille, France.
Luc CeugnartDepartment of imaging, Centre Oscar Lambret, Lille, France.
Claudia RegisDepartment of Surgery, Centre Oscar Lambret, Lille, France.
Loïc BoulangerDepartment of Surgery, Centre Oscar Lambret, Lille, France.
Marie-Pierre ChauvetDepartment of Surgery, Centre Oscar Lambret, Lille, France.
Centre Oscar Lambret · FRHôpital Jeanne de Flandre · FRInstitut de Cancérologie de l'Ouest · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAutologous fat grafting (AFG) is a promising breast reconstruction technique, following surgery. However, fat necrosis after AFG can cause palpable nodules, inducing anxiety and prompting additional investigations. We aimed to determine the occurrence rate and to identify the risk factors of palpable nodules in breast cancer patients prompting complementary explorations. MATERIALS AND

methodsWe retrospectively reviewed the computerized files of consecutive breast cancer patients who underwent AFG after mastectomy or breast conservative treatment (BCT) at our center from January 2013 to December 2016. We collected data regarding palpable nodule incidences and suspicious breast imaging findings that led to additional explorations.

resultsOf the 252 patients reviewed, 222 (88%) underwent AFG for breast reconstruction, while 30 (12%) underwent AFG for correction of defects after BCT. The follow-up period ranged from 0 to 74 months (median: 27 months), and 201 patients had follow-ups beyond 1 year. Of the 252 patients, 66 (26.2%) underwent at least one control imaging and 24 (10%) underwent a biopsy, including 6 (2.4%) locoregional recurrence. Sixty patients (24%) were diagnosed with nodules during follow-ups. Among them, 52 (87%) patients had additional imaging, and 17 patients (28%) had a biopsy, including 82% benign histology. Patients with BCT had significantly more palpable nodules at 1 year than patients who underwent total mastectomy (odds ratio = 2.50, 95% confidence interval: 1.04. 6.03, p = 0.04).

conclusionThis study underlines the importance of preoperative patient information. This intervention and its follow-up should be reserved for experienced teams to limit unnecessary additional explorations. LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Indexed as

Breast NeoplasmsMammaplastyAdipose TissueFemaleFollow-Up StudiesHumansIncidenceMastectomyNeoplasm Recurrence, LocalRetrospective StudiesTransplantation, AutologousTreatment OutcomeAutologous fat graftingBreast cancerLocoregional recurrencePalpable noduleReconstruction

Identifiers

PMID34435220
OpenAlexW3195004173

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.