Evidence map›Paper›PMID 34435215›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2021

Hydrocephalus in myelomeningocele.

Sergio Cavalheiro, Marcos Devanir Silva da Costa, Mauricio Mendes Barbosa, Patricia Alessandra Dastoli, Jardel Nicácio Mendonça, Daniela Cavalheiro, Antonio Fernandes Moron

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Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Outcomes in prenatal vs. postnatal surgery for myelomeningocele: a systematic review and meta-analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Pooled it
  2. From birth to beyond: predicting incidence and timing of CSF diversion in postnatal MMC closure.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026
    Article
  3. Article
  4. Prevalence of spinal deformities in myelomeningoceles treated in utero and postnatally, utilizing 3D external orthopedic system (EOS) panoramic radiographic technology.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Article
  5. Article
  6. Myelomeningocele: Long-Term Neurosurgical Management.Advances and technical standards in neurosurgery · 2024
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Sergio CavalheiroDepartment Neurology and Neurosurgery, Universidade Federal de Sao Paulo, Rua Napoleão de Barros, 715, 6th Floor, Sao Paulo, SP, 04024-002, Brazil.
Marcos Devanir Silva da CostaDepartment Neurology and Neurosurgery, Universidade Federal de Sao Paulo, Rua Napoleão de Barros, 715, 6th Floor, Sao Paulo, SP, 04024-002, Brazil. marcoscostaneuro@gmail.com.ORCID http://orcid.org/0000-0003-3552-6347
Mauricio Mendes BarbosaDepartment of Fetal Medicine, Hospital E Maternidade Santa Joana, São Paulo, SP, Brazil.
Patricia Alessandra DastoliDepartment Neurology and Neurosurgery, Universidade Federal de Sao Paulo, Rua Napoleão de Barros, 715, 6th Floor, Sao Paulo, SP, 04024-002, Brazil.
Jardel Nicácio MendonçaDepartment Neurology and Neurosurgery, Universidade Federal de Sao Paulo, Rua Napoleão de Barros, 715, 6th Floor, Sao Paulo, SP, 04024-002, Brazil.
Daniela CavalheiroFaculdade de Medicina de Jundiaí, Jundiai, SP, Brazil.
Antonio Fernandes MoronDepartment of Fetal Medicine, Hospital E Maternidade Santa Joana, São Paulo, SP, Brazil.
Universidade Federal de São Paulo · BRFaculdade de Medicina de Jundiaí · BRHospital Israelita Albert Einstein · BRHospital Santa Paula · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate certain aspects of hydrocephalus in patients with myelomeningocele.

methodsWe retrospectively analyzed data of 1050 patients with myelomeningocele who underwent surgical treatment between June 1991 and June 2021. These patients were divided into three groups: group 1 consisted of patients who underwent surgery after the first 6 h of life, group 2 consisted of patients who underwent surgery within the first 6 h, and group 3 consisted of patients who underwent surgery during the fetal period and before 26 6/7 weeks of gestation.

resultsThere were 125, 590, and 335 patients in groups 1, 2, and 3, respectively. In groups 1 and 2, 593 (83%) patients developed hydrocephalus after birth and required ventriculoperitoneal shunt placement in the maternity ward, mainly within the first 4 days of life. In contrast, in group 3, 24 (7.2%) patients required surgery to treat hydrocephalus after birth. Hydrocephalus was the primary cause of mortality in groups 1 and 2, with mortality rates of 35% and 10%, respectively. In group 3, the mortality rate was 0.8% and was not related to hydrocephalus.

conclusionThe onset of hydrocephalus is directly related to myelomeningocele closure in neurosurgery.

Indexed as

HydrocephalusMeningomyeloceleFemaleHumansNeurosurgical ProceduresPregnancyRetrospective StudiesVentriculoperitoneal ShuntChiari type IIFetal neurosurgeryFolatesHydrocephalusMyelomeningocele

Identifiers

PMID34435215
OpenAlexW3194312034

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.