Evidence map›Paper›PMID 34435183›Full record

ArticleMatrix biology plus2021

Scaffold-free 3D cell culture of primary skin fibroblasts induces profound changes of the matrisome.

Bich Vu, Glauco R Souza, Jörn Dengjel

Abstract read
In one paragraph

Article in Matrix biology plus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Magnetic-Based Human Tissue 3D Cell Culture: A Systematic Review.International journal of molecular sciences · 2022
    Pooled it
  3. Article
  4. Review
  5. Article
  6. Deep Proteome Profiling of Primary Skin Fibroblasts.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  7. Principles of Hanging Drop Method (Spheroid Formation) in Cell Culture.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Bich VuDepartment of Biology, University of Fribourg, Chemin du Musée 10, CH-1700 Fribourg, Switzerland.
Glauco R SouzaGreiner Bio-One North America, Inc., 4238 Capital Drive, Monroe, NC 28110, USA.
Jörn DengjelDepartment of Biology, University of Fribourg, Chemin du Musée 10, CH-1700 Fribourg, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human skin has a highly developed extracellular matrix (ECM) that is vital for proper skin functioning, its 3D architecture playing a pivotal role in support and guidance of resident and invading cells. To establish relevant

Indexed as

Basement membraneBioprintCollagenECM, extracellular matrixFibroblastMagneticMass spectrometryMatrigelMatrisomeMS, mass spectrometryNanoshuttleNHF, normal human fibroblastProteomicsSCC, squamous cell carcinomaSILAC, stable isotope labelling by amino acids in cell cultureSkin

Identifiers

PMID34435183
PMCPMC8377039

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.