Evidence map›Paper›PMID 34435144›Full record

ArticleHeliyon2021

Synchronous LC-MS/MS determination of pantoprazole and amitriptyline in rabbit plasma: application to comparative in vivo pharmacokinetic study of novel formulated effervescent granules with its marketed tablet dosage form.

Asmaa A El Zaher, Ehab F El Kady, Hussein M El Messiry, Hind E El Ghwas, Ola M El Houssini

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Asmaa A El ZaherPharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., Cairo 11562, Egypt.
Ehab F El KadyPharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., Cairo 11562, Egypt.
Hussein M El MessiryPharmaceutics Department, National Organizations for Drug Control and Research (NODCAR), 51 Wezerat El- Zeraa Street, Agouza, P.O. Box 12553 Giza, 35521, Egypt.
Hind E El GhwasPharmaceutical Chemistry Department, National Organizations for Drug Control and Research (NODCAR), 51 Wezerat El- Zeraa Street, Agouza, P.O. Box 12553 Giza, 35521, Egypt.
Ola M El HoussiniPharmaceutical Chemistry Department, National Organizations for Drug Control and Research (NODCAR), 51 Wezerat El- Zeraa Street, Agouza, P.O. Box 12553 Giza, 35521, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the present study the bioavailability and pharmacokinetics properties of pantoprazole (proton pump inhibitor)/amitriptyline (tricyclic antidepressant) in novel formulated effervescent granules was estimated in rabbit plasma using a validated, selective and rapid LC-MS/MS method. Separation and detection of pantoprazole, amitriptyline and internal standards namely omeprazole and dothiepin, respectively, were achieved at ambient column temperature on C

Indexed as

AmitriptylineBioanalysisEffervescent granulesLC-MS/MSPantoprazolePharmacokinetics

Identifiers

PMID34435144
PMCPMC8375633

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.